KEGG   DRUG: Mecbotamab
Entry
D12219                      Drug                                   
Name
Mecbotamab (USAN)
Formula
C6954H10768N1842O2139S48
Exact mass
155841.7041
Mol weight
155938.17
Sequence
(Heavy chain)
EVQLVQSGAE VKKPGATVKI SCKVSGYSFW GATMNWIRQP PGKGLEWIGL IKPSNGGTSY
NQKFKGRVTI SADKSISTAY LQWSSLKASD TAMYYCAHGH YESYEAMDYW GQGTLVTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV MHEALHNHYT QKSLSLSPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCKASQDVV SAVAWYQQKP GQAPRLLIYW QDTRHTGVPS
RFSGSGSGTE FTLTISSLQP DDFATYYCQE HFSPPLTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H147-H203, H223-L214, H229-H'229, H232-H'232, H264-H324, H370-H428, H'22-H'96, H'147-H'203, H'223-L'214, H'264-H'324, H'370-H'428, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic, Anti-AXL antibody
  Type
Monoclonal antibody
Comment
Treatment of cancers expressing the AXL transmembrane receptor protein
Target
AXL [HSA:558] [KO:K05115]
  Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   AXL family
    AXL
     D12219  Mecbotamab (USAN)
Other DBs
CAS: 2460400-28-4
PubChem: 497620632
LinkDB

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