KEGG   DRUG: Rosnilimab
Entry
D12223                      Drug                                   
Name
Rosnilimab (USAN)
Formula
C6534H10006N1714O2026S42
Exact mass
146242.0901
Mol weight
146332.3596
Sequence
(Heavy chain)
QVQLVQSGSE LKKPGASVKV SCKASNYTFT DYSMHWVRQA PGQGLEWMGW INIETYYPTY
ADQFKGRFAF SLDTSVSTAY LQISSLKAED TAVYYCARDY YGRFYYAMDY WGQGTTVTVS
SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKKVE PKSCDKTHTC PPCPAPELLG
GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY
NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD
ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR
WQQGNVFSCS VMHEALHNHY TQKSLSLSPG
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCTASSSVS SSYFHWYQQK PGQAPRLLIY STSNLASGIP
ARFSGSGSGT DFTLTISRLE PEDFAVYYCH QYHRSPLTFG GGTKVEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H96, H148-H204, H224-L215, H230-H'230, H233-H'233, H265-H325, H371-H429, H'22-H'96, H'148-H'204, H'224-L'215, H'265-H'325, H'371-H'429, L23-L89, L135-L195, L'23-L'89, L'135-L'195)
  Type
Peptide
Efficacy
Autoimmune disease treatment, Immune checkpoint inhibitor
Comment
Monoclonal antibody
Treatment of alopecia areata
Target
PDCD1 (PD1, CD279) [HSA:5133] [KO:K06744]
  Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   Immune checkpoints
    PDCD1 (PD1, CD279)
     D12223  Rosnilimab (USAN)
Other DBs
CAS: 2412764-40-8
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system