KEGG   DRUG: Peresolimab
Entry
D12231                      Drug                                   
Name
Peresolimab (USAN)
Formula
C6440H9976N1694O2033S46
Exact mass
145043.6466
Mol weight
145133.2374
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKVSGYSLS KYDMSWVRQA PGKGLEWMGI IYTSGYTDYA
QKFQGRVTMT EDTSTDTAYM ELSSLRSEDT AVYYCATGNP YYTNGFNSWG QGTLVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCQASQSPN NLLAWYQQKP GKAPKLLIYG ASDLPSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQN NYYVGPVSYA FGGGTKVEIK RTVAAPSVFI
FPPSDEQLKS GTASVVCLLN NFYPREAKVQ WKVDNALQSG NSQESVTEQD SKDSTYSLSS
TLTLSKADYE KHKVYACEVT HQGLSSPVTK SFNRGEC
(Disulfide bridge: H22-H95, H146-H202, H222-L217, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'95, H'146-H'202, H'222-L'217, H'263-H'323, H'369-H'427, L23-L88, L137-L197, L'23-L'88, L'1347-L'197)
  Type
Peptide
Efficacy
Immune checkpoint inhibitor
Comment
Monoclonal antibody
Target
PDCD1 (PD1, CD279) [HSA:5133] [KO:K06744]
  Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   Immune checkpoints
    PDCD1 (PD1, CD279)
     D12231  Peresolimab (USAN)
Other DBs
CAS: 2411580-63-5
LinkDB

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