KEGG   DRUG: Socazolimab
Entry
D12344                      Drug                                   
Name
Socazolimab (USAN)
Formula
C6342H9842N1668O2011S44
Exact mass
142952.6858
Mol weight
143040.8339
Sequence
(Heavy chain)
EVQLVESGAE VKKPGSSVKV SCKASGGTFS SYAISWVRQA PGQGLEWMGG IIPIFGTANY
AQKFQGRVTI TADESTSTAY MELSSLRSED TAVYYCARAP YYYYYMDVWG QGTTVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
QSALTQPASV SGSLGQSVTI SCTGSSSDVG SYNLVSWYQQ HPGKAPNLMI YDVSKRSGVS
NRFSGSKSGN TASLTISGLQ AEDEADYYCS SYTGISTVVF GGGTKLTVLG QPKAAPSVTL
FPPSSEELQA NKATLVCLIS DFYPGAVTVA WKADSSPVKA GVETTTPSKQ SNNKYAASSY
LSLTPEQWKS HRSYSCQVTH EGSTVEKTVA PTECS
(Disulfide bridge: H22-H96, H146-H202, H222-L214, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'96, H'146-H'202, H'222-L'214, H'263-H'323, H'369-H'427, L22-L89, L137-L196, L'22-L'89, L'137-L'196)
  Type
Peptide
Efficacy
Antineoplastic, Immune checkpoint inhibitor, Anti-PD-L1 antibody
Comment
Monoclonal antibody
Target
PDL1 (CD274) [HSA:29126] [KO:K06745]
  Pathway
hsa04514  Cell adhesion molecules
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   Immune checkpoints
    PDL1 (CD274)
     D12344  Socazolimab (USAN)
Other DBs
CAS: 2305043-30-3
LinkDB

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