KEGG   DRUG: Lutikizumab
Entry
D12370                      Drug                                   
Name
Lutikizumab (INN)
Formula
C6454H9900N1694O2017S42
Exact mass
144751.2449
Mol weight
144840.5334
Sequence
(Heavy chain)
EVQLQESGPG LVKPSETLSL TCAVTGYSIT SGYSWHWIRQ FPGNGLEWMG YIHSSGSTNY
NPSLKSRISI SRDTSKNQFF LKLSSVTAAD TAVYYCAGYD DYFEYWGQGT TVTVSSASTK
GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS
LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PEAAGGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN
VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCKASQNVG FNVAWYQQKP GKSPKALIYS ASYRYSGVPS
RFSGSGSGTD FTLTISSLQP EDFAEYFCQQ YNWYPFTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H143-H199, H219-L214, H225-H'225, H228-H'228, H260-H320, H366-H424, H'22-H'96, H'143-H'199, H'219-L'214, H'260-H'320, H'366-H'424, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Class
Immunological agent
 DG02019  Interleukin inhibitor
Efficacy
Anti-inflammatory, Anti-interleukin 1alpha/ beta antibody
Comment
Monoclonal antibody
Treatment of osteoarthritis
Target
IL1 [HSA:3552 3553] [KO:K04383 K04519]
Brite
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D12370  Lutikizumab
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL1
     D12370  Lutikizumab (INN)
Other DBs
CAS: 1791411-57-8
LinkDB

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