KEGG   DRUG: Sibeprenlimab
Entry
D12374                      Drug                                   
Name
Sibeprenlimab (INN);
Sibeprenlimab (genetical recombination) (JAN)
Formula
C6488H10002N1744O2013S52
Exact mass
146217.9379
Mol weight
146308.80
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKASGYTFT DYTIHWVRQA TGQGLEWMGW IYPLRGSINY
AQKFQGRVTM TADKSISTVY MELSSLRSED TAVYFCARHG AYYSNAFDYW GQGTLVTVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER KCCVECPPCP APPVAGPSVF
LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTFR
VVSVLTVVHQ DWLNGKEYKC KVSNKGLPAP IEKTISKTKG QPREPQVYTL PPSREEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPMLDSD GSFFLYSKLT VDKSRWQQGN
VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
EIVMTQSPAT LSVSPGERAT LSCRASESVD NDGIRFLHWY QQKPGQAPRL LIYRASTRAT
GIPARFSGSG SRTEFTLTIS SLQSEDFAVY YCQQSNKDPY TFGGGTKVEI KRTVAAPSVF
IFPPSDEQLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: H22-H96, H134-L218, H147-H203, H222-H'222, H223-H'223, H226-H'226, H229-H'229, H260-H320, H366-H424, H'22-H'96, H'134-L'218, H'147-H'203, H'260-H'320, H'366-H'424, L23-L92, L138-L198, L'23-L'92, L'138-L'198)
  Type
Peptide
Efficacy
Autoimmune disease treatment
  Type
Monoclonal antibody
Comment
Treatment of IgA nephropathy (IgAN)
Target
TNFSF13 (APRIL, CD256) [HSA:8741] [KO:K05475]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04672  Intestinal immune network for IgA production
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF13 (APRIL, CD256)
     D12374  Sibeprenlimab (INN)
Other DBs
CAS: 2382896-07-1
PubChem: 497620787
LinkDB

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