KEGG   DRUG: Tozorakimab
Entry
D12375                      Drug                                   
Name
Tozorakimab (USAN/INN);
Tozorakimab (genetical recombination) (JAN)
Formula
C6414H9956N1708O2006S50
Exact mass
144603.5587
Mol weight
144693.27
Sequence
(Heavy chain)
EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSG ISAIDQSTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARQK FMQLWGGGLR YPFGYWGQGT
MVTVSSASTK GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP
AVLQSSGLYS LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKRVEPKSCD KTHTCPPCPA
PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP
REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL
PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT
VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK
(Light chain)
SYVLTQPPSV SVSPGQTASI TCSGEGMGDK YAAWYQQKPG QSPVLVIYRD TKRPSGIPER
FSGSNSGNTA TLTISGTQAM DEADYYCGVI QDNTGVFGGG TKLTVLGQPK AAPSVTLFPP
SSEELQANKA TLVCLISDFY PGAVTVAWKA DSSPVKAGVE TTTPSKQSNN KYAASSYLSL
TPEQWKSHRS YSCQVTHEGS TVEKTVAPTE CS
(Disulfide bridge: H22-H96, H153-H209, H229-L211, H235-H'235, H238-H'238, H270-H330, H376-H434, H'22-H'96, H'153-H'209, H'229-L'211, H'270-H'330, H'376-H'434, L22-L87, L134-L193, L'22-L'87, L'134-L'193)
  Type
Peptide
Class
Immunological agent
 DG02019  Interleukin inhibitor
Efficacy
Anti-inflammatory, Anti-interleukin 33 antibody
  Type
Monoclonal antibody
Comment
Treatment of COPD, asthma, atopic dermatitis, diabetic kidney disease
Target
IL33 [HSA:90865] [KO:K12967]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04217  Necroptosis
hsa04623  Cytosolic DNA-sensing pathway
Brite
Drug groups [BR:br08330]
 Immunological agent
  DG02019  Interleukin inhibitor
   D12375  Tozorakimab
Target-based classification of drugs [BR:br08310]
 Signaling molecules and receptors
  Cytokines
   Interleukins
    IL33
     D12375  Tozorakimab (USAN/INN)
Other DBs
CAS: 2376858-66-9
PubChem: 497620788
LinkDB

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