KEGG   DRUG: Petosemtamab
Entry
D12416                      Drug                                   
Name
Petosemtamab (USAN/INN)
Formula
C6479H9972N1714O2040S46
Exact mass
145899.6412
Mol weight
145989.83
Sequence
(Heavy chain)
EVQLVQSGSK LKKPGASVKV SCKASGYTFT SYTMNWVRQA PGQGLEWMGW INTDTGDPTY
AQGFTGRFVF SLDTSVSTAF LQINSLKAED TAVYYCARGD CDSTSCYRYS YGYEDYWGQG
TLVTVSSAST KGPSVFPLAP SSKSTSGGTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF
PAVLQSSGLY SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDKRVEPKSC DKTHTCPPCP
APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK
PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT
KPPSREEMTK NQVSLKCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL
TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSP
(heavy chain)
XVQLVQSGSE LKKPGASVKI SCKASGYDFT NYAMNWVRQA PGHGLEWMGW INANTGDPTY
AQGFTGRFVF SLDTSVSTAY LQISSLKAED SAVYYCTRER FLEWLHFDYW GQGTLVTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPELLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTDPPSREE
MTKNQVSLTC EVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV MHEALHNHYT QKSLSLSPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQSIS SYLNWYQQKP GKAPKLLIYA ASSLQSGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ SYSTPPTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H101-H106, H154-H210, H230-L214, H236-h229, H239-h232, H271-H331, H377-H435, h22-h96, h147-h203, h223-L'214, h264-h324, h370-h428, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic
  Type
Bispecific antibody
Comment
Treatment of cancer
Target
EGFR [HSA:1956] [KO:K04361]
LGR5 [HSA:8549] [KO:K04308]
  Pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04310  Wnt signaling pathway
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   R-spondin
    LGR5
     D12416  Petosemtamab (USAN/INN)
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    EGFR
     D12416  Petosemtamab (USAN/INN)
Other DBs
CAS: 2213450-26-9
PubChem: 497620829
LinkDB

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