KEGG   DRUG: Paltusotine hydrochloride
Entry
D12478                      Drug                                   
Name
Paltusotine hydrochloride (JAN/USAN);
Palsonify (TN)
Product
PALSONIFY (Crinetics Pharmaceuticals)
Formula
C27H22F2N4O. HCl
Exact mass
492.1528
Mol weight
492.94
Structure
Class
Hormonal agent
 DG01588  Somatostatin receptor agonist
Remark
ATC code: H01CB06
Chemical structure group: DG03248
Product (DG03248): D12478<US>
Efficacy
Antineoplastic, Somatostatin receptor agonist
  Disease
Acromegaly [DS:H01483]
Comment
Treatment of acromegaly, carcinoid syndrome and neuroendocrine tumors
Target
SSTR2 [HSA:6752] [KO:K04218]
  Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04935  Growth hormone synthesis, secretion and action
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01C HYPOTHALAMIC HORMONES
    H01CB Somatostatin and analogues
     H01CB06 Paltusotine
      D12478  Paltusotine hydrochloride (JAN/USAN) <US>
Drug groups [BR:br08330]
 Hormonal agent
  DG01588  Somatostatin receptor agonist
   DG03248  Paltusotine
    D12478  Paltusotine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Somatostatin
    SSTR2
     D12478  Paltusotine hydrochloride (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12478
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12478
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12478
Drug groups [BR:br08330]
 Hormonal agent
  DG01588  Somatostatin receptor agonist
   DG03248  Paltusotine
Other DBs
CAS: 2361216-83-1
PubChem: 497620891
LinkDB
KCF data

ATOM        35
            1   C8y C    16.8381  -18.1008
            2   C8x C    16.8381  -19.5040
            3   C8x C    18.0308  -20.2056
            4   C8y C    19.2937  -19.5040
            5   C8y C    19.2937  -18.1008
            6   C8x C    18.0308  -17.3992
            7   N5x N    20.4864  -20.2056
            8   C8x C    21.6790  -19.5040
            9   C8y C    21.6790  -18.1008
            10  C8y C    20.4864  -17.3992
            11  C8y C    22.9419  -17.3992
            12  C8x C    24.1346  -18.1008
            13  C8y C    25.3273  -17.3992
            14  C8x C    25.3273  -15.9961
            15  C8y C    24.1346  -15.2945
            16  C8x C    22.9419  -15.9961
            17  C8y C    15.6454  -17.3992
            18  C8x C    15.6454  -15.9961
            19  C8x C    14.3826  -15.2945
            20  C8x C    13.1899  -15.9961
            21  C8y C    13.1899  -17.3992
            22  C8y C    14.3826  -18.1008
            23  O1a O    14.3826  -19.5040
            24  C3b C    11.9972  -18.1008
            25  N3a N    10.7344  -18.8024
            26  X   F    26.5200  -18.1008
            27  X   F    24.1346  -13.8913
            28  N1y N    20.4864  -15.9961
            29  C1x C    21.6790  -15.2945
            30  C1x C    21.6790  -13.8913
            31  C1y C    20.4864  -13.1897
            32  C1x C    19.2937  -13.8913
            33  C1x C    19.2937  -15.2945
            34  N1a N    20.4864  -11.7866
            35  X   Cl   26.0400  -20.4400
BOND        38
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    9  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   11  16 1
            19    1  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 2
            23   20  21 1
            24   21  22 2
            25   17  22 1
            26   22  23 1
            27   21  24 1
            28   24  25 3
            29   13  26 1
            30   15  27 1
            31   10  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   28  33 1
            38   31  34 1

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