| Entry |
|
|---|
| Name |
Lotiglipron (USAN) |
|---|
| Formula |
C31H31ClN4O5
|
|---|
| Exact mass |
574.1983
|
|---|
| Mol weight |
575.05
|
|---|
| Structure |
|
|---|
| Class |
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
|
|---|
| Remark |
|
|---|
| Efficacy |
Antidiabetic, Antiobesity, Glucagon-like peptide 1 (GLP-1) receptor agonist |
|---|
| Comment |
Treatment of type-2 diabetes mellitus, obesity and non-alcoholic steatohepatitis
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
DG03281 Lotiglipron
D12555 Lotiglipron
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Secretin receptor family
Glucagon
GLP1R
D12555 Lotiglipron (USAN)
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
DG03281 Lotiglipron
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 41
1 C8y C 16.1700 -19.3900
2 C8x C 16.1700 -20.7900
3 C8x C 17.3600 -21.4900
4 C8x C 18.6200 -20.7900
5 C8y C 18.6200 -19.3900
6 C8y C 17.3600 -18.6900
7 C1y C 19.8100 -18.6900
8 C1x C 21.0000 -19.3900
9 C1x C 22.1900 -18.6900
10 N1y N 22.1900 -17.2900
11 C1x C 21.0000 -16.5900
12 C1x C 19.8100 -17.2900
13 C1b C 23.4500 -16.5900
14 C8y C 24.6400 -17.2900
15 N4y N 24.5700 -18.6900
16 C8y C 25.9000 -19.1800
17 C8y C 26.8100 -18.0600
18 N5x N 25.9700 -16.8700
19 C1b C 23.4500 -19.4600
20 C1y C 23.4500 -20.8600
21 O2x O 22.4700 -21.8400
22 C1x C 23.4500 -22.8200
23 C1x C 24.4300 -21.8400
24 C8x C 26.4600 -20.4400
25 C8y C 27.7900 -20.6500
26 C8x C 28.7000 -19.5300
27 C8x C 28.1400 -18.2700
28 C6a C 28.3500 -21.9100
29 O6a O 29.6800 -22.1200
30 O6a O 27.4400 -23.0300
31 O2x O 15.1200 -18.4800
32 C1z C 15.6800 -17.2200
33 O2x O 17.0800 -17.3600
34 C8y C 14.9800 -16.0300
35 C8x C 13.5800 -16.0300
36 C8x C 12.8800 -14.8400
37 C8y C 13.5800 -13.5800
38 C8x C 14.9800 -13.5800
39 N5x N 15.6800 -14.7700
40 X Cl 12.8800 -12.3900
41 C1a C 14.2800 -17.2200
BOND 47
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 7 12 1
14 10 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 16 17 2
19 17 18 1
20 14 18 2
21 15 19 1
22 20 19 1 #Down
23 20 21 1
24 21 22 1
25 22 23 1
26 20 23 1
27 16 24 1
28 24 25 2
29 25 26 1
30 26 27 2
31 17 27 1
32 25 28 1
33 28 29 1
34 28 30 2
35 1 31 1
36 31 32 1
37 32 33 1
38 6 33 1
39 32 34 1 #Up
40 34 35 2
41 35 36 1
42 36 37 2
43 37 38 1
44 38 39 2
45 34 39 1
46 37 40 1
47 32 41 1 #Down
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