KEGG   DRUG: Quisovalimab
Entry
D12648                      Drug                                   
Name
Quisovalimab (USAN/INN)
Formula
C6414H9880N1692O2022S40
Exact mass
144239.1127
Mol weight
144327.87
Sequence
(Heavy chain)
QVQLQQWGAG LLKPSETLSL TCAVYGGSFS GYNWHWIRQP PGKGLEWIGE ITHSGSTNYN
PSLKSRVTIS VDTSKNQFSL KLSSVTAADT AVYYCVREIA VAGTGYYGMD VWGQGTTVTV
SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV ESKYGPPCPP CPAPEFEGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY VDGVEVHNAK TKPREEQFNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK AKGQPREPQV YTLPPSQEEM
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS RLTVDKSRWQ
EGNVFSCSVM HEALHNHYTQ KSLSLSLG
(Light chain)
AIQLTQSPSS LSASVGDRVT ITCRASQGIN SAFAWYQQKP GKAPKLLIYD ASSLESGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ FNSYPLTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H95, H136-L214, H149-H205, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'95, H'136-L'214, H'149-H'205, H'263-H'323, H'369-H'427, L23-L88, L134-194, L'23-L'88, L'134-L194)
  Type
Peptide
Efficacy
Anti-inflammatory
  Type
Monoclonal antibody
Comment
Treatment of Crohn's disease, prevention of ARDS in patients with COVID-19
Target
TNFSF14 [HSA:8740] [KO:K05477]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04064  NF-kappa B signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF14
     D12648  Quisovalimab (USAN/INN)
Other DBs
CAS: 2427667-03-4
PubChem: 497621061
LinkDB

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