| Entry |
|
|---|
| Name |
Lotiglipron tromethamine (USAN) |
|---|
| Formula |
C31H31ClN4O5. C4H11NO3
|
|---|
| Exact mass |
695.2722
|
|---|
| Mol weight |
696.19
|
|---|
| Structure |
|
|---|
| Class |
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
|
|---|
| Remark |
|
|---|
| Efficacy |
Antidiabetic, Antiobesity, Glucagon-like peptide 1 (GLP-1) receptor agonist |
|---|
| Comment |
Treatment of type 2 diabetes, obesity and non- alcoholic steatohepatitis
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
DG03281 Lotiglipron
D12735 Lotiglipron tromethamine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Secretin receptor family
Glucagon
GLP1R
D12735 Lotiglipron tromethamine (USAN)
Drug groups [BR:br08330]
Antidiabetic agent
DG02044 Hypoglycemic agent
DG01493 GLP-1 receptor agonist
DG03281 Lotiglipron
|
|---|
| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 49
1 C8y C 13.5538 -17.6972
2 C8x C 13.5538 -19.1017
3 C8x C 14.7477 -19.8040
4 C8x C 16.0117 -19.1017
5 C8y C 16.0117 -17.6972
6 C8y C 14.7477 -16.9949
7 C1y C 17.2056 -16.9949
8 C1x C 18.3995 -17.6972
9 C1x C 19.5933 -16.9949
10 N1y N 19.5933 -15.5904
11 C1x C 18.3995 -14.8881
12 C1x C 17.2056 -15.5904
13 C1b C 20.8574 -14.8881
14 C8y C 22.0513 -15.5904
15 N4y N 21.9810 -16.9949
16 C8y C 23.3154 -17.4865
17 C8y C 24.2283 -16.3629
18 N5x N 23.3856 -15.1690
19 C1b C 20.8574 -17.7674
20 C1y C 20.8574 -19.1720
21 O2x O 19.8742 -20.1551
22 C1x C 20.8574 -21.1383
23 C1x C 21.8406 -20.1551
24 C8x C 23.8772 -18.7506
25 C8y C 25.2115 -18.9613
26 C8x C 26.1244 -17.8377
27 C8x C 25.5626 -16.5736
28 C6a C 25.7733 -20.2254
29 O6a O 27.1076 -20.4360
30 O6a O 24.8603 -21.3490
31 O2x O 12.5004 -16.7842
32 C1z C 13.0622 -15.5202
33 O2x O 14.4668 -15.6606
34 C8y C 12.3599 -14.3263
35 C8x C 10.9554 -14.3263
36 C8x C 10.2531 -13.1324
37 C8y C 10.9554 -11.8684
38 C8x C 12.3599 -11.8684
39 N5x N 13.0622 -13.0622
40 X Cl 10.2531 -10.6745
41 C1a C 11.6577 -15.5202
42 C1b C 30.6600 -15.4000
43 C1d C 31.8724 -16.1000
44 O1a O 29.4476 -16.1000
45 C1b C 33.0679 -15.4096
46 O1a O 34.2553 -16.0951
47 N1a N 31.8724 -14.7000
48 C1b C 31.8724 -17.5000
49 O1a O 33.0680 -18.1903
BOND 54
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 7 12 1
14 10 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 16 17 2
19 17 18 1
20 14 18 2
21 15 19 1
22 20 19 1 #Down
23 20 21 1
24 21 22 1
25 22 23 1
26 20 23 1
27 16 24 1
28 24 25 2
29 25 26 1
30 26 27 2
31 17 27 1
32 25 28 1
33 28 29 1
34 28 30 2
35 1 31 1
36 31 32 1
37 32 33 1
38 6 33 1
39 32 34 1 #Up
40 34 35 2
41 35 36 1
42 36 37 2
43 37 38 1
44 38 39 2
45 34 39 1
46 37 40 1
47 32 41 1 #Down
48 42 43 1
49 42 44 1
50 43 45 1
51 45 46 1
52 43 47 1
53 43 48 1
54 48 49 1
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