KEGG   DRUG: Denecimig
Entry
D12797                      Drug                                   
Name
Denecimig (USAN/INN);
Denecimig (genetical recombination) (JAN)
Formula
C6464H9949N1712O2024S45
Exact mass
145380.5643
Mol weight
145470.42
Sequence
(A chain)
EVQLVESGGG LVQPGRSLRL SCAASGFTFH DYAMHWVRQV PGKGLEWVSG ISWRGDIGGY
VKSVKGRFTI SRDNAKNSLY LQMNSLRAED TALYYCVKSY GSGSFYNAFD SWGQGTLVTV
SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV ESKYGPPCPP CPAPEFLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY VDGVEVHNAK TKPREEQFNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK AKGQPREPQV YTLPPSQEEM
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS RLTVDKSRWQ
EGNVFSCSVM HEALHNHYTQ KSLSLSLG
(B chain)
EVQLVQSGAE VKKPGESLRI SCKGSGYSFS TSWIVWVRQM PGKGLEWMGM IDPSDSFTSY
SPSFQGHVTI SADKSISTAY LQWSSLKASD TAMYYCARLH YYNSEEFDVW GQGTLVTVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPPCP APEFLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFLLYSKL TVDKSRWQEG
NVFSCSVMHE ALHNHYTQKS LSLSLG
(C chain)
EIVLTQSPGT LSLSPGERAT LSCRASQSVS SSYLAWYQQK PGQAPRLLIY GQSSRTRGIP
DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QFGDSQLFTF GQGTKLEIKR TVAAPSVFIF
PPSDEQLKSG TASVVCLLNN FYPREAKVQW KVDNALQSGN SQESVTEQDS KDSTYSLSST
LTLSKADYEK HKVYACEVTH QGLSSPVTKS FNRGEC
(D chain)
DIQMTQSPST LSASVGDRVT ITCRASQSIS SWLAWYQQKP GKAPKFLIYK ASKLERGTPS
RFSGSGSGTE FSLTISSLQP DDFATYYCLE YSSYIRTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: A22-A96, A136-D214, A149-A205, A228-B226, A231-B229, A263-A323, A369-A427, B22-B96, B134-C216, B147-B203, B261-B321, B367-B425, C23-C89, C136-C196 D23-D88, D134-D194)
  Type
Peptide
Efficacy
Bleeding suppressant
  Type
Monoclonal antibody, bispecific antibody
Comment
Prevention of bleeding episodes in patients with hemophilia
Target
F9a [CPD:C03259] [HSA:2158] [KO:K01321]
F10 [HSA:2159] [KO:K01314]
  Pathway
hsa04610  Complement and coagulation cascades
Brite
Target-based classification of drugs [BR:br08310]
 Peptidases and inhibitors
  Serine peptidases
   Chymotrypsin family
    F9a
     D12797  Denecimig (USAN/INN)
    F10
     D12797  Denecimig (USAN/INN)
Other DBs
CAS: 2488745-86-2
PubChem: 497621210
LinkDB

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