KEGG   DRUG: Temtokibart
Entry
D12824                      Drug                                   
Name
Temtokibart (USAN/INN)
Formula
C6288H9700N1680O1996S40
Exact mass
141961.7996
Mol weight
142049.03
Sequence
(Heavy chain)
QVQLVESGGG LVQPGGSLRL SCAASGFTFS SYDMNWVRQA PGKGLEWVSS IYNDASNTAY
SDSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKVG FSGTYYSESW GQGTLVTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYQ
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK
(Light chain)
SYELTQPSSV SVALGQTARI TCQGGYYAHW YQQKPGQAPV LVIYGQNNRP SGIPERFSGS
GAGNTATLTI SRAQAEDEAD YYCQSGSSSS NAVFGGGTKL TVLGQPKAAP SVTLFPPSSE
ELQANKATLV CLISDFYPGA VTVAWKADSS PVKAGVETTT PSKQSNNKYA ASSYLSLTPE
QWKSHRSYSC QVTHEGSTVE KTVAPTECS
(Disulfide bridge: H22-H96, H147-H203,H223-L208, H229-H'229, H232-H'232, H264-H324, H370-H428, H'22-H'96, H'147-H'203, H'223-L'208, H'264-H'324, H'370-H'428, L22-L83, L131-L190, L'22-L'83, L'131-L'190)
  Type
Peptide
Efficacy
Anti-inflammatory, Anti-IL-22 receptor antibody
  Type
Monoclonal antibody
Comment
Treatment of moderate to severe atopic dermatitis
Target
IL22RA1 [HSA:58985] [KO:K05138]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  JAK-STAT signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Signaling molecules and receptors
  Cytokine receptors
   Interleukin receptors
    IL22RA1
     D12824  Temtokibart (USAN/INN)
Other DBs
CAS: 2639874-57-8
PubChem: 497621237
LinkDB

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