KEGG   DRUG: Sabirnetug
Entry
D12873                      Drug                                   
Name
Sabirnetug (USAN/INN)
Formula
C6416H9922N1722O2000S50
Exact mass
144693.3662
Mol weight
144783.12
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS SFGMHWVRQA PGKGLEWVAY ISRGSSTIYY
ADTVKGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCARGI TTALDYWGQG TLVTVSSAST
KGPSVFPLAP CSRSTSESTA ALGCLVKDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SNFGTQTYTC NVDHKPSNTK VDKTVERKCC VECPPCPAPP VAGPSVFLFP
PKPKDTLMIS RTPEVTCVVV DVSHEDPEVQ FNWYVDGVEV HNAKTKPREE QFNSTFRVVS
VLTVVHQDWL NGKEYKCKVS NKGLPAPIEK TISKTKGQPR EPQVYTLPPS REEMTKNQVS
LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPMLDSDGSF FLYSKLTVDK SRWQQGNVFS
CSVMHEALHN HYTQKSLSLS PGK
(Light chain)
DVVMTQSPLS LPVTPGEPAS ISCRSSQSIV HSNGNTYLEW YLQKPGQSPQ LLIYKASNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCFQGSRLG PSFGQGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H131-L219, H144-H200, H219-H'219, H220-H'220, H223-H'223, H226-H'226, H257-H317, H363-H421, H'22-H'96, H'131-L'219, H'144-H'200, H'257-H'317, H'363-H'421, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Efficacy
  Type
Monoclonal antibody
Comment
Treatment of Alzheimer's disease
Target
APP [HSA:351] [KO:K04520]
  Pathway
hsa04726  Serotonergic synapse
hsa05010  Alzheimer disease
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Nervous system
    APP
     D12873  Sabirnetug (USAN/INN)
Other DBs
CAS: 2747959-38-0
PubChem: 497621286
LinkDB

» Japanese version   » Back

DBGET integrated database retrieval system