| Entry |
|
|---|
| Name |
Azetukalner (USAN/INN);
Encukalner |
|---|
| Formula |
C23H29FN2O
|
|---|
| Exact mass |
368.2264
|
|---|
| Mol weight |
368.49
|
|---|
| Structure |
|
|---|
| Efficacy |
Antidepressant, Potassium channel modulator |
|---|
| Comment |
For the treatment of partial-onset seizures, primary generalized tonic-clonic seizures and major depressive disorder
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Potassium channels
KCNQ2
D12890 Azetukalner (USAN/INN)
KCNQ3
D12890 Azetukalner (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 27
1 C8y C 16.1000 -13.4400
2 C8y C 16.1000 -14.8400
3 C8y C 14.9100 -15.5400
4 C8x C 13.6500 -14.8400
5 C8y C 13.6500 -13.4400
6 C8x C 14.9100 -12.7400
7 C1a C 14.9100 -16.9400
8 N1b N 17.2900 -15.5400
9 C5a C 18.4800 -14.8400
10 C1b C 19.6700 -15.5400
11 O5a O 18.4800 -13.4400
12 C1a C 17.2900 -12.7400
13 C1d C 20.8600 -14.8400
14 C1a C 22.0500 -15.5400
15 C1a C 21.5600 -13.6500
16 C1a C 20.1600 -13.6500
17 N1y N 12.4600 -12.7400
18 C1x C 11.2700 -13.4400
19 C8y C 10.0100 -12.7400
20 C8y C 10.0100 -11.3400
21 C1x C 11.2000 -10.6400
22 C1x C 12.4600 -11.3400
23 C8x C 8.8200 -13.4400
24 C8x C 7.6300 -12.7400
25 C8y C 7.6300 -11.3400
26 C8x C 8.8200 -10.6400
27 X F 6.4400 -10.6400
BOND 29
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 3 7 1
8 2 8 1
9 8 9 1
10 9 10 1
11 9 11 2
12 1 12 1
13 10 13 1
14 13 14 1
15 13 15 1
16 13 16 1
17 5 17 1
18 17 18 1
19 18 19 1
20 19 20 1
21 20 21 1
22 21 22 1
23 17 22 1
24 19 23 2
25 23 24 1
26 24 25 2
27 25 26 1
28 20 26 2
29 25 27 1
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|---|
