KEGG   DRUG: Veligrotug
Entry
D12952                      Drug                                   
Name
Veligrotug (USAN/INN);
Veligrotug-vvze;
Lumvoa (TN)
Formula
C6580H10160N1752O2038S40
Exact mass
147609.4068
Mol weight
147700.26
Sequence
(Heavy chain)
QVQLVQSGAE VVKPGASVKL SCKASGYTFT SYWMHWVKQR PGQGLEWIGE INPSNGRTNY
NQKFQGKATL TVDKSSSTAY MQLSSLTSED SAVYYFARGR PDYYGSSKWY FDVWGQGTTV
TVSSASTKGP SVFPLAPSSK STSGGTAALG CLVKDYFPEP VTVSWNSGAL TSGVHTFPAV
LQSSGLYSLS SVVTVPSSSL GTQTYICNVN HKPSNTKVDK KVEPKSCDKT HTCPPCPAPE
LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE
EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP
SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD
KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGK
(Light chain)
DVVMTQTPLS LPVSLGDPAS ISCRSSQSIV HSNVNTYLEW YLQKPGQSPR LLIYKVSNRF
SGVPDRFSGS GAGTDFTLRI SRVEAEDLGI YYCFQGSHVP PTFGGGTKLE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H151-H207, H227-L219, H233-H'233, H236-H'236, H268-H328, H374-H432, H'151-H'207, H'227-L'219, H'268-H'328, H'374-H'432, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Efficacy
Autoimmune disease treatment, Anti-IGF1R antibody
  Disease
Thyroid eye disease [DS:H02402]
  Type
Monoclonal antibody
Comment
Treatment of thyroid eye disease
Target
IGF1R (CD221) [HSA:3480] [KO:K05087]
  Pathway
hsa04144  Endocytosis
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    IGF1R (CD221)
     D12952  Veligrotug (USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12952
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12952
Other DBs
CAS: 2728655-31-8
PubChem: 500141102
LinkDB

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