KEGG   DRUG: Azirkitug
Entry
D13130                      Drug                                   
Name
Azirkitug (USAN/INN)
Formula
C6466H10016N1724O2006S44
Exact mass
145320.2450
Mol weight
145410.00
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLKL SCAASGFIFS NAVMYWVRQA SGKGLEWVAR IKTKFNNYAT
YYADAVKGRF TISRDDSKNM VYLQMNSLKT EDTAVYYCTA GDRNKPFAYW GQGTLVTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE
MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK
(Light chain)
ETVVTQSPAT LSLSPGERAT LSCRASTSVI TLLHWFQQKP GQAPRLLIHG ASNLESRVPA
RFSGSGSGTD FTLTISSLEP EDFATYFCQQ SWNDPYTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H98, H147-H203, H223-L214, H229-H'229, H232-H'232, H370-H428, H264-H324, H'22-H'98, H'147-H'203, H'223-L'214, H'370-H'428, H'264-H'324, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Efficacy
Antineoplastic, Immunomodulator
  Type
Monoclonal antibody
Comment
Treatment of solid tumors
Target
CCR8 [HSA:1237] [KO:K04183]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Chemokine receptors
    CCR8
     D13130  Azirkitug (USAN/INN)
Other DBs
CAS: 2837169-12-5
PubChem: 513757667
LinkDB

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