KEGG   DRUG: Vimseltinib dihydrate
Entry
D13166                      Drug                                   
Name
Vimseltinib dihydrate;
Romvimza (TN)
Product
ROMVIMZA (Deciphera Pharmaceuticals)
Formula
C23H25N7O2. 2H2O
Exact mass
467.2281
Mol weight
467.52
Structure
Remark
ATC code: L01EX29
Chemical structure group: DG03359
Product (DG03359): D13166<US>
Efficacy
Antineoplastic
  Disease
Tenosynovial giant cell tumor
Target
CSF1R (FMS, CD115) [HSA:1436] [KO:K05090]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04380  Osteoclast differentiation
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX29 Vimseltinib
      D13166  Vimseltinib dihydrate <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Multitargeted Kinase Inhibitors, CSF1R
    Vimseltinib
     D13166  Vimseltinib dihydrate
Target-based classification of drugs [BR:br08310]
 Signaling molecules and receptors
  Cytokine receptors
   CSF and other factor receptors
    CSF1R (FMS, CD115)
     D13166  Vimseltinib dihydrate <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D13166
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D13166
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D13166
Other DBs
CAS: 3084810-15-8
PubChem: 519518016
LinkDB
KCF data

ATOM        34
            1   N5x N    13.7118  -15.5307
            2   C8y C    13.7118  -16.9298
            3   C8x C    14.9710  -17.6294
            4   C8y C    16.1603  -16.9298
            5   C8x C    16.1603  -15.5307
            6   C8x C    14.9710  -14.8311
            7   O2a O    17.4195  -17.6294
            8   C8y C    18.6088  -16.9298
            9   C8x C    19.7981  -17.6294
            10  C8x C    20.9874  -16.9298
            11  C8y C    20.9874  -15.4607
            12  N5x N    19.7981  -14.8311
            13  C8y C    18.6088  -15.5307
            14  C8y C    22.2466  -14.7611
            15  C8y C    23.4359  -15.4607
            16  N4y N    24.6252  -14.7611
            17  C8y C    24.6252  -13.3620
            18  N5x N    23.4359  -12.6624
            19  C8x C    22.2466  -13.3620
            20  O5x O    23.4359  -16.9298
            21  C1a C    25.8845  -15.4607
            22  C1a C    27.0737  -14.7611
            23  C1c C    27.0737  -13.3620
            24  N1b N    25.8845  -12.6624
            25  C1a C    28.2630  -12.6624
            26  C1a C    17.3496  -14.7611
            27  C8y C    12.5225  -17.6294
            28  C8x C    11.2632  -17.0698
            29  N4y N    10.3538  -18.0492
            30  N5x N    11.0534  -19.2384
            31  C8x C    12.3826  -18.9586
            32  C1a C     8.8847  -17.9092
            33  O0  O    26.6000  -19.0400
            34  O0  O    29.5400  -18.9700
BOND        35
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   14  19 2
            22   15  20 2
            23   16  21 1
            24   22  23 1
            25   23  24 1
            26   17  24 1
            27   23  25 1
            28   13  26 1
            29    2  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 1
            33   30  31 2
            34   27  31 1
            35   29  32 1

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