Entry
Name
Tambiciclib (USAN/INN)
Formula
C25H35ClN6O2S
Exact mass
518.2231
Mol weight
519.10
Structure
Mol file KCF file DB search
Class
Antineoplastic
DG03138 CDK inhibitor
Efficacy
Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor
Comment
Treatment of relapsed/refractory hematologic malignancies
Target
Pathway
hsa05202 Transcriptional misregulation in cancer
Brite
Drug groups [BR:br08330 ]
Antineoplastic
DG03138 CDK inhibitor
D13188 Tambiciclib
Target-based classification of drugs [BR:br08310 ]
Protein kinases
Serine/threonine kinases
CMGC group
CDK9
D13188 Tambiciclib (USAN/INN)
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 35
1 C1x C 24.4300 -13.0200
2 C1y C 24.4300 -11.6200
3 C1x C 23.2400 -10.9200
4 C1x C 21.9800 -11.6200
5 C1y C 21.9800 -13.0200
6 C1x C 23.2400 -13.7200
7 N1b N 20.7900 -13.7200
8 C8y C 19.6000 -13.0200
9 N5x N 19.6000 -11.6200
10 C8x C 18.3400 -10.9200
11 C8y C 17.1500 -11.6200
12 C8y C 17.1500 -13.0200
13 C8x C 18.3400 -13.7200
14 X Cl 15.9600 -10.9200
15 C8y C 15.9600 -13.7200
16 N5x N 14.6300 -13.3000
17 C8y C 13.7900 -14.4200
18 S2x S 14.6300 -15.5400
19 C8x C 15.9600 -15.1200
20 N1b N 12.3900 -14.4200
21 C1b C 11.6200 -15.6100
22 C1z C 10.2200 -15.6100
23 C1x C 9.5200 -14.4200
24 C1x C 8.1200 -14.4200
25 O2x O 7.4200 -15.6800
26 C1x C 8.1200 -16.8700
27 C1x C 9.5200 -16.8700
28 N1b N 25.6200 -10.9200
29 C1c C 26.8100 -11.6200
30 C1b C 28.0000 -10.9200
31 O2a O 29.1900 -11.6200
32 C1a C 30.3800 -10.9200
33 C3b C 10.9200 -16.8000
34 N3a N 11.6200 -18.0600
35 C1a C 26.8100 -13.0200
BOND 38
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 5 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 11 14 1
16 12 15 1
17 15 16 1
18 16 17 2
19 17 18 1
20 18 19 1
21 15 19 2
22 17 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 25 26 1
29 26 27 1
30 22 27 1
31 2 28 1
32 28 29 1
33 29 30 1
34 30 31 1
35 31 32 1
36 22 33 1
37 33 34 3
38 29 35 1 #Up