| Entry |
|
|---|
| Name |
Tenofovir alafenamide monofumarate (USAN) |
|---|
| Formula |
C21H29N6O5P. C4H4O4
|
|---|
| Exact mass |
592.2047
|
|---|
| Mol weight |
592.54
|
|---|
| Structure |
|
|---|
| Class |
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
|
|---|
| Remark |
| Product (DG01223): | D01982<JP/US> D10605<JP/US> |
|
|---|
| Efficacy |
Antiviral, Reverse transcriptase inhibitor |
|---|
| Comment |
Prevention or treatment of HIV infection
|
|---|
| Target |
HIV-1 reverse transcriptase [KO: K24802] |
|---|
| Pathway |
| ko03260 | Virion - Human immunodeficiency virus |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF13 Tenofovir alafenamide
D13304 Tenofovir alafenamide monofumarate (USAN)
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01223 Tenofovir
D13304 Tenofovir alafenamide monofumarate
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG01223 Tenofovir
D13304 Tenofovir alafenamide monofumarate
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01223 Tenofovir
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG01223 Tenofovir
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 41
1 N5x N 21.4200 -12.8800
2 C8x C 21.4200 -14.3500
3 N5x N 20.2300 -15.0500
4 C8y C 19.0400 -14.3500
5 C8y C 19.0400 -12.8800
6 C8y C 20.2300 -12.1800
7 N4y N 17.7100 -14.7700
8 C8x C 16.9400 -13.6500
9 N5x N 17.7100 -12.4600
10 N1a N 20.2300 -10.8500
11 C1b C 17.7100 -16.1700
12 C1c C 16.5200 -16.8700
13 O2a O 15.2600 -16.1700
14 C1b C 14.2100 -16.8700
15 P1a P 12.9500 -16.1700
16 C1a C 16.5200 -18.2000
17 O2b O 11.6900 -15.4700
18 O3b O 13.6500 -14.9100
19 N1b N 11.8300 -17.3600
20 C8y C 10.2900 -15.4700
21 C8x C 9.5900 -14.2800
22 C8x C 8.1900 -14.2800
23 C8x C 7.4900 -15.4700
24 C8x C 8.1900 -16.6600
25 C8x C 9.5900 -16.6600
26 C1c C 11.8300 -18.7600
27 C7a C 10.6400 -19.4600
28 C1a C 13.0200 -19.4600
29 O7a O 9.4500 -18.7600
30 O6a O 10.6400 -20.8600
31 C1c C 8.2600 -19.4600
32 C1a C 7.0700 -18.7600
33 C1a C 8.2600 -20.8600
34 C6a C 27.7900 -16.5900
35 C2b C 28.9800 -17.2900
36 O6a O 26.6000 -17.2900
37 O6a O 27.7900 -15.1900
38 C2b C 30.1700 -16.5900
39 C6a C 31.3600 -17.2900
40 O6a O 32.5500 -16.5900
41 O6a O 31.3600 -18.6900
BOND 42
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 2
10 5 9 1
11 6 10 1
12 7 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 12 16 1 #Up
18 15 17 1 #Up
19 15 18 2
20 15 19 1 #Down
21 17 20 1
22 20 21 2
23 21 22 1
24 22 23 2
25 23 24 1
26 24 25 2
27 20 25 1
28 19 26 1
29 26 27 1
30 26 28 1 #Up
31 27 29 1
32 27 30 2
33 29 31 1
34 31 32 1
35 31 33 1
36 34 35 1
37 34 36 1
38 34 37 2
39 35 38 2
40 38 39 1
41 39 40 1
42 39 41 2
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