| Entry |
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| Name |
Shigellosis;
Bacillary dysentery |
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| Description |
Shigellosis (bacillary dysentery) is a foodborne enterobacterial infection caused by Shigella species. There are four subgroups of Shigella: S. dysenteriae, S. flexneri, S. boydii, and S. sonnei. Of these, S. flexneri is the most frequently observed worldwide, and S. dysenteriae causes severe disease with the highest fatality rate. Transmission usually occurs via contaminated food and water or through person-to-person contact.
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| Category |
Infectious disease
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| Brite |
Infectious diseases [BR:br08401]
Bacterial infections
Infections caused by enterobacteria
H00299 Shigellosis
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
Gastroenteritis or colitis of infectious origin
Bacterial intestinal infections
1A02 Intestinal infections due to Shigella
H00299 Shigellosis
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| Pathway |
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| Network |
nt06121 TLR signaling (viruses and bacteria) nt06123 TNF signaling (viruses and bacteria) nt06128 Autophagy (viruses and bacteria) nt06131 Apoptosis (viruses and bacteria) nt06134 CGAS-STING signaling (viruses and bacteria) nt06135 Cytoskeletal regulation (viruses and bacteria) nt06139 NLR signaling (viruses and bacteria) |
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| Element |
| N00927 | Escherichia/Shigella NleE/OspZ to TNF-NFKB signaling pathway |
| N00941 | Shigella IpaH9.8 to NOD-NFKB signaling pathway |
| N00942 | Shigella OspG to TNF-NFKB signaling pathway |
| N00943 | Shigella IpaH4.5 to TNF-NFKB signaling pathway |
| N00944 | Shigella OspI to TNF-NFKB signaling pathway |
| N00945 | Shigella IpaH1.4/2.5 to TNF-NFKB signaling pathway |
| N00946 | Shigella IpaJ to cGAS-STING signaling pathway |
| N00947 | Shigella Ipa4.5 to cGAS-STING signaling pathway |
| N00948 | Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway |
| N00949 | Shigella IpaB to NLRC4 Inflammasome signaling pathway |
| N00950 | Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways |
| N00952 | Shigella IpgB1 to ITGA/B-RHOG-RAC signaling pathway |
| N01067 | Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway |
| N01069 | Shigella IpgB1 to ITGA/B-FAK-RAC signaling pathway |
| N01071 | Shigella IpgB1 to ITGA/B-FAK-CDC42 signaling pathway |
| N01073 | Shigella IpgB2 to ITGA/B-RhoGEF-RhoA signaling pathway |
| N01074 | Shigella IpaA to ITGA/B-RhoGEF-RhoA signaling pathway |
| N01075 | Shigella IcsB to ITGA/B-RhoGEF-RhoA signaling pathway |
| N01076 | Shigella IcsB to ITGA/B-FAK-CDC42 signaling pathway |
| N01077 | Shigella IcsB to ITGA/B-FAK-RAC signaling pathway |
| N01079 | Shigella IpaC to Actin signaling pathway |
| N01081 | Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway |
| N01082 | Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway |
| N01083 | Shigella OspE to ITGA/B-TALIN/VINCULIN signaling pathway |
| N01283 | Shigella OspF to TLR2/4-MAPK signaling pathway |
| N01284 | Shigella IcsP to Autophagy-vesicle elongation |
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| Pathogen |
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| Drug |
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| Other DBs |
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| Reference |
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| Authors |
Kweon MN |
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| Title |
Shigellosis: the current status of vaccine development. |
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| Journal |
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| Reference |
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| Authors |
Warren BR, Parish ME, Schneider KR |
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| Title |
Shigella as a foodborne pathogen and current methods for detection in food. |
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| Journal |
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| Reference |
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| Authors |
Niyogi SK |
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| Title |
Shigellosis. |
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| Journal |
J Microbiol 43:133-43 (2005) |
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| LinkDB |
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