KEGG   DISEASE: Chagas disease
Entry
H00358                      Disease                                
Name
Chagas disease;
American trypanosomiasis
Description
Chagas disease, also known as American trypanosomiasis, is caused by infection with protozoan parasite Trypanosoma cruzi. The infection is transmitted by hematophagous reduviid insect vectors through fecal contamination. The majority of infected individuals live in Latin American countries. Chagas disease is characterized by an acute phase followed by a chronic phase, with sustained inflammation that causes cardiomyopathy, digestive disorders, and neuropathies.
Category
Parasitic infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Parasitic diseases
   Nonintestinal protozoal diseases
    1F53  Chagas disease
     H00358  Chagas disease
Genome-based classification of infectious diseases [BR:br08401]
 Parasitic infections (protists)
  Infections caused by Euglenozoa
   H00358  Chagas disease
Disease
pathway
hsa05142  Chagas disease
Pathogen
Trypanosoma cruzi [GN:tcr]
Drug
Nifurtimox [DR:D00833]
Comment
Vector: Rhodnius prolixus (Reduviid bug)
Other DBs
ICD-11: 1F53
MeSH: D014355
MedlinePlus: 001372
Reference
  Authors
Bern C
  Title
Chagas' Disease.
  Journal
N Engl J Med 373:456-66 (2015)
DOI:10.1056/NEJMra1410150
Reference
  Authors
Guarner J
  Title
Chagas disease as example of a reemerging parasite.
  Journal
Semin Diagn Pathol 36:164-169 (2019)
DOI:10.1053/j.semdp.2019.04.008
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