KEGG DISEASE: Acne inversa

DISEASE: Acne inversa

Entry

H00681                      Disease

Name

Acne inversa;
Hidradenitis suppurativa

Description

Acne inversa (AI), also known as hidradenitis suppurativa, is a chronic inflammatory disorder of hair follicles involving the apocrine gland-bearing areas of the body. Its characteristic features include recurrent formation of painful skin abscesses, fistulating sinuses, and disfiguring scars.

Category

Skin disease

Brite

Human diseases in ICD-11 classification [BR:br08403]
14 Diseases of the skin
  Skin disorders involving specific cutaneous structures
   Disorders of the epidermis and epidermal appendages
    Disorders of the hair follicle
     ED92  Disorders involving the apocrine follicular unit
      H00681  Acne inversa
Pathway-based classification of diseases [BR:br08402]
Signal transduction
  nt06511  NOTCH signaling
   H00681  Acne inversa

Pathway

hsa04330

Notch signaling pathway

Network

nt06511 NOTCH signaling

Gene

(ACNINV1) NCSTN [HSA:23385] [KO:K06171]
(ACNINV2) PSENEN [HSA:55851] [KO:K06170]
(ACNINV3) PSEN1 [HSA:5663] [KO:K04505]

Drug

Adalimumab [DR:D02597]

Other DBs

ICD-11:

ED92.0