KEGG   DISEASE: Acne inversa
Entry
H00681                      Disease                                

Name
Acne inversa;
Hidradenitis suppurativa
Description
Acne inversa (AI), also known as hidradenitis suppurativa, is a chronic inflammatory disorder of hair follicles involving the apocrine gland-bearing areas of the body. Its characteristic features include recurrent formation of painful skin abscesses, fistulating sinuses, and disfiguring scars.
Category
Skin disease
Brite
Human diseases [BR:br08402]
 Skin diseases
  Skin and soft tissue diseases
   H00681  Acne inversa
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Skin disorders involving specific cutaneous structures
   Disorders of the epidermis and epidermal appendages
    Disorders of the hair follicle
     ED92  Disorders involving the apocrine follicular unit
      H00681  Acne inversa
Related
pathway
hsa04310  Wnt signaling pathway
hsa04330  Notch signaling pathway
hsa04722  Neurotrophin signaling pathway
Gene
PSENEN [HSA:55851] [KO:K06170]
PSEN1 [HSA:5663] [KO:K04505]
NCSTN [HSA:23385] [KO:K06171]
Env factor
Smoking
Staphylococci infection
Androgen levels
Drug
Adalimumab [DR:D02597]
Other DBs
ICD-11: ED92.0
ICD-10: L73.2
MeSH: D017497
OMIM: 142690 613736 613737
Reference
PMID:21192260 (description, env_factor, drug)
  Authors
Yazdanyar S, Jemec GB
  Title
Hidradenitis suppurativa: a review of cause and treatment.
  Journal
Curr Opin Infect Dis 24:118-23 (2011)
DOI:10.1097/QCO.0b013e3283428d07
Reference
PMID:17958790 (drug)
  Authors
Lam J, Krakowski AC, Friedlander SF
  Title
Hidradenitis suppurativa (acne inversa): management of a recalcitrant disease.
  Journal
Pediatr Dermatol 24:465-73 (2007)
DOI:10.1111/j.1525-1470.2007.00544.x
Reference
PMID:15264991 (drug)
  Authors
Jemec GB
  Title
Medical treatment of hidradenitis suppurativa.
  Journal
Expert Opin Pharmacother 5:1767-70 (2004)
DOI:10.1517/14656566.5.8.1767
Reference
  Authors
Li CR, Jiang MJ, Shen DB, Xu HX, Wang HS, Yao X, Zhang Y, Zhou WQ, Wang B
  Title
Two novel mutations of the nicastrin gene in Chinese patients with acne inversa.
  Journal
Br J Dermatol 165:415-8 (2011)
DOI:10.1111/j.1365-2133.2011.10372.x
Reference
  Authors
Wang B, Yang W, Wen W, Sun J, Su B, Liu B, Ma D, Lv D, Wen Y, Qu T, Chen M, Sun M, Shen Y, Zhang X
  Title
Gamma-secretase gene mutations in familial acne inversa.
  Journal
Science 330:1065 (2010)
DOI:10.1126/science.1196284
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