KEGG DISEASE: Delayed sleep phase syndrome

KEGG

DISEASE: Delayed sleep phase syndrome

Entry

H00689                      Disease

Name

Delayed sleep phase syndrome

Description

Delayed sleep phase syndrome (DSPS) is characterized by a 3 to 6-hour delayed sleep schedule relative to the desired. The single nucleotide polymorphism (Ala129Thr) in Arylalkylamine N-acetyltransferase (AANAT), a rate-limiting enzyme in melatonin synthesis, has been identified in patients with delayed sleep phase disorder.

Category

Nervous system disease

Brite

Human diseases [BR:br08402]
Nervous system diseases
  Other nervous and sensory system diseases
   H00689  Delayed sleep phase syndrome
Human diseases in ICD-11 classification [BR:br08403]
07 Sleep-wake disorders
  Circadian rhythm sleep-wake disorders
   7A60  Delayed sleep-wake phase disorder
    H00689  Delayed sleep phase syndrome

Related
pathway

Tryptophan metabolism

Circadian rhythm

Gene

AANAT (polymorphism) [HSA:15] [KO:K00669]
CRY1 [HSA:1407] [KO:K02295]

Other DBs

ICD-11:

ICD-10:

MeSH:

OMIM:

Reference

Authors

Barion A

Title

Circadian rhythm sleep disorders.

Journal

Dis Mon 57:423-37 (2011)
DOI:10.1016/j.disamonth.2011.06.003

Reference

Authors

Bjorvatn B, Pallesen S

Title

A practical approach to circadian rhythm sleep disorders.

Journal

Sleep Med Rev 13:47-60 (2009)
DOI:10.1016/j.smrv.2008.04.009

Reference

Authors

Hohjoh H, Takasu M, Shishikura K, Takahashi Y, Honda Y, Tokunaga K

Title

Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome.

Journal

Neurogenetics 4:151-3 (2003)
DOI:10.1007/s10048-002-0141-9

Reference

Authors

Patke A, Murphy PJ, Onat OE, Krieger AC, Ozcelik T, Campbell SS, Young MW

Title

Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.

Journal

Cell 169:203-215.e13 (2017)
DOI:10.1016/j.cell.2017.03.027

LinkDB

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