KEGG   DISEASE: Onchocerciasis
Entry
H01043                      Disease                                
Name
Onchocerciasis;
River blindness;
Robles disease
  Supergrp
Filariasis [DS:H02028]
Description
Human onchocerciasis is an infection caused by the filarial nematode Onchocerca volvulus transmitted by Simulium blackflies. The disease is endemic in sub-Saharan African countries, the Arabian peninsula, and small parts of Latin America. Persons with onchocerciasis may develop skin diseases such as pruritus, lichenification, and depigmentation, as well as ocular manifestations. Onchocerca volvulus contain Wolbachia bacteria as mutualistic symbionts, and these Wolbachia affects the nematode survival.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Parasitic infections (animals)
  Infections caused by nematodes
   H01043  Onchocerciasis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Parasitic diseases
   Helminthiases
    Diseases due to nematodes
     1F6A  Onchocerciasis
      H01043  Onchocerciasis
Pathogen
Onchocerca volvulus
Drug
Ivermectin [DR:D00804]
Moxidectin [DR:D05084]
Comment
Vector: Simulium blackflies
Other DBs
ICD-11: 1F6A
ICD-10: B73
MeSH: D009855
Reference
  Authors
Taylor MJ, Hoerauf A, Bockarie M
  Title
Lymphatic filariasis and onchocerciasis.
  Journal
Lancet 376:1175-85 (2010)
DOI:10.1016/S0140-6736(10)60586-7
Reference
  Authors
Cupp EW, Sauerbrey M, Richards F
  Title
Elimination of human onchocerciasis: history of progress and current feasibility using ivermectin (Mectizan((R))) monotherapy.
  Journal
Acta Trop 120 Suppl 1:S100-8 (2011)
DOI:10.1016/j.actatropica.2010.08.009
Reference
  Authors
Tamarozzi F, Halliday A, Gentil K, Hoerauf A, Pearlman E, Taylor MJ
  Title
Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment.
  Journal
Clin Microbiol Rev 24:459-68 (2011)
DOI:10.1128/CMR.00057-10
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