KEGG   DISEASE: Liver fluke disease
Entry
H01048                      Disease                                
Name
Liver fluke disease;
Fascioliasis
  Supergrp
Foodborne trematodiasis [DS:H01617]
Description
Fascioliasis is a foodborne zoonotic disease caused by the liver flukes Fasciola hepatica and Fasciola gigantica. Whereas in Europe, the Americas and Oceania only F. hepatica is concerned, the distributions of both species overlap in many areas of Africa and Asia. An infection is accomplished through oral ingestion of the infective stage of the parasite either through consumption of uncooked or unwashed aquatic plants, or through drinking contaminated water. The presence of F. hepatica flukes in humans was first documented in 1760.
Category
Parasitic infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Parasitic diseases
   Helminthiases
    Diseases due to trematodes
     1F82  Fascioliasis
      H01048  Liver fluke disease
Genome-based classification of infectious diseases [BR:br08401]
 Parasitic infections (animals)
  Infections caused by flat worms
   H01048  Liver fluke disease
Pathogen
Fasciola hepatica
Fasciola gigantica
Drug
Triclabendazole [DR:D07364]
Comment
Intermediate host: freshwater snail species of the family Lymnaeidae
Other DBs
ICD-11: 1F82
MeSH: D005211
Reference
  Authors
Marcos LA, Terashima A, Gotuzzo E
  Title
Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis.
  Journal
Curr Opin Infect Dis 21:523-30 (2008)
DOI:10.1097/QCO.0b013e32830f9818
Reference
  Authors
Keiser J, Engels D, Buscher G, Utzinger J
  Title
Triclabendazole for the treatment of fascioliasis and paragonimiasis.
  Journal
Expert Opin Investig Drugs 14:1513-26 (2005)
DOI:10.1517/13543784.14.12.1513
Reference
  Authors
Mas-Coma S, Bargues MD, Valero MA
  Title
Fascioliasis and other plant-borne trematode zoonoses.
  Journal
Int J Parasitol 35:1255-78 (2005)
DOI:10.1016/j.ijpara.2005.07.010
Reference
  Authors
Keiser J, Utzinger J
  Title
Food-borne trematodiases.
  Journal
Clin Microbiol Rev 22:466-83 (2009)
DOI:10.1128/CMR.00012-09
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