KEGG DISEASE: Staphylococcal infection

KEGG

DISEASE: Staphylococcal infection

Entry

H01175                      Disease

Name

Staphylococcal infection

Description

Staphylococci are widespread as commensals of humans and animals where they colonize the skin or mucous membranes. Firstly, Staphylococcus lugdunensis is a most unusual coagulase-negative staphylococcus found on the human skin. It can cause infections at many sites including superficial skin infections, bacteremia, endocarditis, osteomyelitis, and breast abscess. Endocarditis caused by S. lugdunensis can lead to substantial morbidity and mortality. Secondly, Staphylococcus haemolyticus, found among the normal skin flora, is commonly isolated from the axillae, perineum, and inguinal areas of humans and causes septicemia, peritonitis, otitis, and urinary tract infections. S. haemolyticus is notorious for its multidrug resistance and historically early acquisition of resistance to methicillin and glycopeptide antibiotics. Finally, Staphylococcus pseudintermedius is an important opportunistic pathogen of dogs and cats. S. pseudintermedius colonization is very uncommon in humans. It is rarely isolated from human dog-bite wounds. The infection has been associated with wide range of symptoms such as bacteremia, a brain abscess, and pneumonia.

Category

Bacterial infectious disease

Brite

Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
  Gastroenteritis or colitis of infectious origin
   Bacterial foodborne intoxications
    1A10  Foodborne staphylococcal intoxication
     H01175  Staphylococcal infection
Genome-based classification of infectious diseases [BR:br08401]
Bacterial infections
  Infections caused by Gram-positive bacteria
   H01175  Staphylococcal infection

Pathogen

Staphylococcus lugdunensis [GN:slg sln]
Staphylococcus haemolyticus [GN:sha]
Staphylococcus pseudintermedius

Drug

Vancomycin hydrochloride [DR:D00926]
Bacitracin [DR:D00128]
Clindamycin palmitate hydrochloride [DR:D01990]
Clindamycin hydrochloride [DR:D02132]

Comment

Treatment was most commonly initiated with vancomycin and narrowed as antibiotic susceptibilities allowed.
Methicillin resistance has been reported.

Other DBs

ICD-11:

MeSH:

Reference

Authors

Klotchko A, Wallace MR, Licitra C, Sieger B

Title

Staphylococcus lugdunensis: an emerging pathogen.

Journal

South Med J 104:509-14 (2011)
DOI:10.1097/SMJ.0b013e31821e91b1

Reference

Authors

Liu PY, Huang YF, Tang CW, Chen YY, Hsieh KS, Ger LP, Chen YS, Liu YC

Title

Staphylococcus lugdunensis infective endocarditis: a literature review and analysis of risk factors.

Journal

J Microbiol Immunol Infect 43:478-84 (2010)
DOI:10.1016/S1684-1182(10)60074-6

Reference

Authors

Chopra A, Gulati D, Woldenberg N, Singh M

Title

Intracardiac lead endocarditis due to Staphylococcus lugdunensis.

Journal

Int J Infect Dis 14 Suppl 3:e291-3 (2010)
DOI:10.1016/j.ijid.2009.12.008

Reference

Authors

Pada S, Lye DC, Leo YS, Barkham T

Title

Utility of 16S ribosomal DNA sequencing in the diagnosis of Staphylococcus lugdunensis native valve infective endocarditis: case report and literature review.

Journal

Int J Infect Dis 13:e511-3 (2009)
DOI:10.1016/j.ijid.2009.02.019

Reference

Authors

van Duijkeren E, Catry B, Greko C, Moreno MA, Pomba MC, Pyorala S, Ruzauskas M, Sanders P, Threlfall EJ, Torren-Edo J, Torneke K

Title

Review on methicillin-resistant Staphylococcus pseudintermedius.

Journal

J Antimicrob Chemother 66:2705-14 (2011)
DOI:10.1093/jac/dkr367

Reference

Authors

Fitzgerald JR

Title

The Staphylococcus intermedius group of bacterial pathogens: species re-classification, pathogenesis and the emergence of meticillin resistance.

Journal

Vet Dermatol 20:490-5 (2009)
DOI:10.1111/j.1365-3164.2009.00828.x

Reference

Authors

Weese JS, van Duijkeren E

Title

Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine.

Journal

Vet Microbiol 140:418-29 (2010)
DOI:10.1016/j.vetmic.2009.01.039

Reference

Authors

Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K.

Title

Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.

Journal

J Bacteriol 187:7292-308 (2005)
DOI:10.1128/JB.187.21.7292-7308.2005

LinkDB

» Japanese version

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