KEGG   DISEASE: Idiopathic macular hole
Entry
H01480                      Disease                                
Name
Idiopathic macular hole;
Retinal perforations
Description
Idiopathic macular hole is a common cause of visual impairment in people in their sixth decade or older, with a higher prevalence in females. Although existing theories of macular hole pathogenesis are constantly being changed and refined, nearly all confirm the predominant role of the vitreous in their formation. Until 1991, it was considered an untreatable condition, but now interventions are carried out to close the hole and thereby improve the central visual defect. Initially, vitrectomy surgery with long-acting gas (SF6, C3F8) and postoperative face-down positioning for at least 1 week was the only option. However, nowadays, there are a number of possible treatment choices including ocriplasmin treatment.
Category
Nervous system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 09 Diseases of the visual system
  Disorders of the eyeball posterior segment
   Disorders of the retina
    9B75  Macular disorders
     H01480  Idiopathic macular hole
Other DBs
ICD-11: 9B75.1
MeSH: D012167
Reference
  Authors
Madi HA, Masri I, Steel DH
  Title
Optimal management of idiopathic macular holes.
  Journal
Clin Ophthalmol 10:97-116 (2016)
DOI:10.2147/OPTH.S96090
Reference
  Authors
Xirou T, Xirou V, Mangouritsas G, Feretis E, Kabanarou SA
  Title
Full Thickness Macular Hole Closure after Exchanging Silicone-Oil Tamponade with C(3)F(8) without Posturing.
  Journal
Case Rep Ophthalmol 2:166-9 (2011)
DOI:10.1159/000327695
Reference
  Authors
Stalmans P, Benz MS, Gandorfer A, Kampik A, Girach A, Pakola S, Haller JA
  Title
Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes.
  Journal
N Engl J Med 367:606-15 (2012)
DOI:10.1056/NEJMoa1110823
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