KEGG   DISEASE: Vitamin C deficiency
Entry
H01580                      Disease                                

Name
Vitamin C deficiency;
Scurvy
Description
Scurvy occurs because of reduced intake or absorption of vitamin C, which is characterized by bleeding gums, impaired wound healing, petechiae, perifollicular hemorrhage, anemia, arthralgia and joint effusions, fatigue, depression, and sudden death. It appears to result primarily from the decreased synthesis of collagen, a major protein in the body dependent on vitamin C for its biosynthesis. However, this role of vitamin C does not explain all of the manifestations associated with scurvy. At-risk groups include the poor (because of reduced access to groceries), food faddists, and individuals with purported allergies to multiple fruit and vegetable products. Other at-risk groups include persons with gastrointestinal disease (e.g. colitis), anatomical abnormalities, poor dentition, cancer patients on chemotherapy, patients on hemodialysis, and psychiatric disorders (e.g. depression, schizophrenia, or anorexia). Alcoholic persons represent one of the largest groups at risk for scurvy because they may have poorly balanced diets and because alcohol decreases the absorption of vitamin C. The diagnosis of scurvy is generally based on clinical features and dietary history, and there is rapid resolution of signs and symptoms after vitamin C supplementation.
Category
Hematologic disease; Cardiovascular disease; Metabolic disease
Brite
Human diseases [BR:br08402]
 Cardiovascular diseases
  Hematologic diseases
   H01580  Vitamin C deficiency
Human diseases in ICD-11 classification [BR:br08403]
 05 Endocrine, nutritional or metabolic diseases
  Nutritional disorders
   Undernutrition
    5B56  Vitamin C deficiency
     H01580  Vitamin C deficiency
Drug
Ascorbic acid [DR:D00018]
Other DBs
ICD-11: 5B56
ICD-10: E54
MeSH: D012614
Reference
PMID:7946525
  Authors
Sauberlich HE
  Title
Pharmacology of vitamin C.
  Journal
Annu Rev Nutr 14:371-91 (1994)
DOI:10.1146/annurev.nu.14.070194.002103
Reference
PMID:16911372 (description, drug)
  Authors
Olmedo JM, Yiannias JA, Windgassen EB, Gornet MK
  Title
Scurvy: a disease almost forgotten.
  Journal
Int J Dermatol 45:909-13 (2006)
DOI:10.1111/j.1365-4632.2006.02844.x
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