KEGG   DISEASE: IgA vasculitis
H01584                      Disease                                
IgA vasculitis;
Henoch-Schonlein purpura
IgA vasculitis (IgAV), also known as Henoch-Schonlein purpura (HSP), is the most common systemic small vessel vasculitis in childhood with clinical characteristics of non-thrombocytopenic palpable purpura, arthritis, and involvement of internal organs such as gastrointestine (GI) and kidney. IgAV has been associated with a history of preceding infections, especially upper respiratory tract infection. In addition, other characteristics of IgAV include the deposition of IgA and C3 in small vessel walls, polymorphonuclear neutrophil infiltration around the vessel and in vessel walls, and increased serum levels of IgA and proinflammatory cytokines at the acute stage. Combined, IgAV is regarded as a specific immune-mediated entity induced by environmental factors, particularly infections. Clinically, since there are no disease-specific laboratory abnormalities, IgAV is currently diagnosed based on symptoms and signs and histopathological findings. Treatment is supportive because IgAV is usually self-limiting except for serious GI or renal involvement.
Cardiovascular disease
Human diseases [BR:br08402]
 Cardiovascular diseases
  Hematologic diseases
   H01584  IgA vasculitis
Human diseases in ICD-11 classification [BR:br08403]
 04 Diseases of the immune system
  Nonorgan specific systemic autoimmune disorders
   4A44  Vasculitis
    H01584  IgA vasculitis
Other DBs
ICD-11: 4A44.92
ICD-10: D69.0
MeSH: D011695
Yang YH, Yu HH, Chiang BL
The diagnosis and classification of Henoch-Schonlein purpura: an updated review.
Autoimmun Rev 13:355-8 (2014)
He X, Yu C, Zhao P, Ding Y, Liang X, Zhao Y, Yue X, Wu Y, Yin W
The genetics of Henoch-Schonlein purpura: a systematic review and meta-analysis.
Rheumatol Int 33:1387-95 (2013)

» Japanese version

DBGET integrated database retrieval system