KEGG DISEASE: Chronic eosinophilic leukemia

KEGG

DISEASE: Chronic eosinophilic leukemia

Entry

H01590                      Disease

Name

Chronic eosinophilic leukemia

Description

Chronic eosinophilic leukemia (CEL) is a chronic myeloproliferative disease of unknown etiology in which a clonal proliferation of eosinophilic precursors results in a persistently elevated number of eosinophils in blood, bone marrow or peripheral tissues. In most patients with CEL (about 60%), eosinophils display PDGFRA-fusion genes and related cytogenetic defects. The most commonly detected oncoprotein is FIP1L1/PDGFRA. FIP1L1-PDGFRA is a constitutively activated tyrosine kinase, which is suggested to induce the proliferation of EoL-1 (The eosinophilic leukemia cell line) cells by inducing c-Myc expression at the mRNA level via ERK and JNK signaling pathways.

Category

Cancer

Brite

Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Neoplasms of haematopoietic or lymphoid tissues
   Myeloproliferative neoplasms
    2A20  Non mast cell myeloproliferative neoplasms
     H01590  Chronic eosinophilic leukemia

Gene

FIP1L1-PDGFRA (deletion) [HSA:5156] [KO:K04363]
BCR-PDGFRA (translocation) [HSA:5156] [KO:K04363]

Drug

Imatinib mesylate [DR:D01441] (FIP1L1-PDGFRA positive)

Other DBs

ICD-11:

MeSH:

Reference

Authors

Gotlib J, Cools J, Malone JM 3rd, Schrier SL, Gilliland DG, Coutre SE

Title

The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management.

Journal

Blood 103:2879-91 (2004)
DOI:10.1182/blood-2003-06-1824

Reference

Authors

Kumar A, Sinha S, Tripathi AK

Title

Chronic eosinophilic leukemia: a case report and review of literature.

Journal

Indian J Hematol Blood Transfus 23:112-5 (2007)
DOI:10.1007/s12288-008-0010-2

Reference

Authors

Yamada Y, Rothenberg ME, Cancelas JA

Title

Current concepts on the pathogenesis of the hypereosinophilic syndrome/chronic eosinophilic leukemia.

Journal

Transl Oncogenomics 1:53-63 (2006)

Reference

Authors

Gotlib J, Cross NC, Gilliland DG

Title

Eosinophilic disorders: molecular pathogenesis, new classification, and modern therapy.

Journal

Best Pract Res Clin Haematol 19:535-69 (2006)
DOI:10.1016/j.beha.2005.07.013

Reference

Authors

Valent P

Title

Pathogenesis, classification, and therapy of eosinophilia and eosinophil disorders.

Journal

Blood Rev 23:157-65 (2009)
DOI:10.1016/j.blre.2009.01.001

Reference

Authors

Ishihara K, Kitamura H, Hiraizumi K, Kaneko M, Takahashi A, Zee O, Seyama T, Hong J, Ohuchi K, Hirasawa N

Title

Mechanisms for the proliferation of eosinophilic leukemia cells by FIP1L1-PDGFRalpha.

Journal

Biochem Biophys Res Commun 366:1007-11 (2008)
DOI:10.1016/j.bbrc.2007.12.063

Reference

Authors

De Keersmaecker K, Cools J

Title

Chronic myeloproliferative disorders: a tyrosine kinase tale.

Journal

Leukemia 20:200-5 (2006)
DOI:10.1038/sj.leu.2404064

LinkDB

» Japanese version

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