KEGG   DISEASE: Endometriosis
Entry
H01639                      Disease                                

Name
Endometriosis
Description
Endometriosis is defined as the growth of the endometrial glands and stroma at extra-uterine sites, which are most commonly implanted over and under visceral and peritoneal surfaces within the female pelvis but which can also be found in the connective tissue in the pelvis areas and, more rarely, in any anatomic district. It is a major cause of infertility, dysmenorrhea, dyspareunia, and chronic pelvic pain, mediated by marked pelvic inflammation. While retrograde menstruation is the most widely accepted cause, its pathogenesis and natural course are not fully understood. Endometriosis is known to be a estrogen-dependent disease, manifests during reproductive years.
Category
Reproductive system disease
Brite
Human diseases [BR:br08402]
 Reproductive system diseases
  Reproductive system diseases
   H01639  Endometriosis
Human diseases in ICD-11 classification [BR:br08403]
 16 Diseases of the genitourinary system
  Diseases of the female genital system
   Noninflammatory disorders of female genital tract
    GA10  Endometriosis
     H01639  Endometriosis
Env factor
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) [CPD:C07557]
Polyhalogenated aromatic hydrocarbon chemicals (PHAHs)
Polychlorinated biphenyls (PCBs)
Drug
Medroxyprogesterone acetate [DR:D00951]
Danazol [DR:D00289]
Nafarelin acetate [DR:D00990]
Elagolix sodium [DR:D09336]
Leuprolide acetate [DR:D00989]
Goserelin acetate [DR:D00573]
Other DBs
ICD-11: GA10
ICD-10: N80
MeSH: D004715
Reference
PMID:24927773 (env_factor, marker)
  Authors
Aznaurova YB, Zhumataev MB, Roberts TK, Aliper AM, Zhavoronkov AA
  Title
Molecular aspects of development and regulation of endometriosis.
  Journal
Reprod Biol Endocrinol 12:50 (2014)
DOI:10.1186/1477-7827-12-50
Reference
PMID:25578564 (marker)
  Authors
Signorile PG, Baldi A
  Title
New evidence in endometriosis.
  Journal
Int J Biochem Cell Biol 60:19-22 (2015)
DOI:10.1016/j.biocel.2014.12.019
Reference
  Authors
Vercellini P, Vigano P, Somigliana E, Fedele L
  Title
Endometriosis: pathogenesis and treatment.
  Journal
Nat Rev Endocrinol 10:261-75 (2014)
DOI:10.1038/nrendo.2013.255
Reference
PMID:26125255 (env_factor)
  Authors
Soave I, Caserta D, Wenger JM, Dessole S, Perino A, Marci R
  Title
Environment and Endometriosis: a toxic relationship.
  Journal
Eur Rev Med Pharmacol Sci 19:1964-72 (2015)
Reference
PMID:26050551 (drug)
  Authors
Lindsay SF, Luciano DE, Luciano AA
  Title
Emerging therapy for endometriosis.
  Journal
Expert Opin Emerg Drugs 20:449-61 (2015)
DOI:10.1517/14728214.2015.1051966
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2015, Fifty-Fourth Edition
  Journal
McGraw Hill Education
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