KEGG   DISEASE: Chilblains
Entry
H01643                      Disease                                
Name
Chilblains;
Pernio
Description
Chilblains, or pernio, is a localized inflammatory lesion of the skin resulting from an abnormal response to cold. It is characterized by persistent purple or purple-red nodules on acral skin, most commonly the feet. Chilblains occurs most commonly among young women between the ages of 15 and 30 years but may occur among older individuals or children. Treatment of chilblains is focused on keeping the affected area warm, and occasionally using vasodilator agents.
Category
Immune system disease; Skin disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 22 Injury, poisoning or certain other consequences of external causes
  Other or unspecified effects of external causes
   NF03  Other effects of reduced temperature
    H01643  Chilblains
Other DBs
ICD-11: NF03.0
MeSH: D002647
Reference
  Authors
Simon TD, Soep JB, Hollister JR
  Title
Pernio in pediatrics.
  Journal
Pediatrics 116:e472-5 (2005)
DOI:10.1542/peds.2004-2681
Reference
  Authors
Al-Sudany NK
  Title
Treatment of primary perniosis with oral pentoxifylline (a double-blind placebo-controlled randomized therapeutic trial).
  Journal
Dermatol Ther 29:263-8 (2016)
DOI:10.1111/dth.12350
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