KEGG   DISEASE: Obesity hypoventilation syndrome
Entry
H01715                      Disease                                
Name
Obesity hypoventilation syndrome;
Pickwickian Syndrome
Description
Obesity hypoventilation syndrome (OHS) is defined as the triad of obesity (BMI of 30 or higher), daytime hypoventilation, and sleep-disordered breathing in the absence of any other cause of hypoventilation. The features include marked obesity, somnolence, twitching, cyanosis, periodic respiration, polycythemia, and right ventricular hypertrophy and failure. Patients with untreated OHS have a significant risk of death. While continuous positive airway pressure (CPAP) treatments may temporize cardiopulmonary disease progression, simultaneous pursuit of weight reduction is central to long-term management of this condition.
Category
Respiratory system disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 07 Sleep-wake disorders
  Sleep-related breathing disorders
   7A42  Sleep-related hypoventilation or hypoxemia disorders
    H01715  Obesity hypoventilation syndrome
Other DBs
ICD-11: 7A42.0
MeSH: D010845
OMIM: 257500
Reference
  Authors
Mokhlesi B
  Title
Obesity hypoventilation syndrome: a state-of-the-art review.
  Journal
Respir Care 55:1347-62; discussion 1363-5 (2010)
Reference
  Authors
Chanda A, Kwon JS, Wolff AJ, Manthous CA
  Title
Positive pressure for obesity hypoventilation syndrome.
  Journal
Pulm Med 2012:568690 (2012)
DOI:10.1155/2012/568690
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