KEGG   DISEASE: Membranoproliferative glomerulonephritis
Entry
H01726                      Disease                                
Name
Membranoproliferative glomerulonephritis
  Subgroup
Dense deposit disease (DDD)
C3 glomerulopathy (C3G) [DS:H02579]
Immunoglobulin-mediated membranoproliferative glomerulonephritis
Description
Membranoproliferative glomerulonephritis (MPGN) represents a pattern of glomerular injury, characterized by mesangial proliferation and expansion, lobularization of the glomerular tufts, and double contours. Classification of MPGN has been updated in the 2010s and is now categorized according to the immunofluorescence microscopy findings. MPGN is now recognized as follows: Immunocomplexes-associated MPGN with complement over activation; MPGN with intramembranous dense deposits; and C3 glomerulopathy.
Category
Immune system disease; Urinary system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01726  Membranoproliferative glomerulonephritis
 Urinary system diseases
  Kidney diseases
   H01726  Membranoproliferative glomerulonephritis
Human diseases in ICD-11 classification [BR:br08403]
 21 Symptoms, signs or clinical findings, not elsewhere classified
  Symptoms, signs or clinical findings of the genitourinary system
   Clinical findings in specimens from the urinary system
    MF8Y  Other specified clinical findings in specimens from the urinary system
     H01726  Membranoproliferative glomerulonephritis
Related
pathway
hsa04610  Complement and coagulation cascades
Gene
CFH [HSA:3075] [KO:K04004]
CFHR5 [HSA:81494] [KO:K23817]
DGKE [HSA:8526] [KO:K00901]
Other DBs
ICD-11: MF8Y
ICD-10: N03
MeSH: D015432
OMIM: 609814 614809 615008
Reference
  Authors
Lionaki S, Gakiopoulou H, Boletis JN
  Title
Understanding the complement-mediated glomerular diseases: focus on membranoproliferative glomerulonephritis and C3 glomerulopathies.
  Journal
APMIS 124:725-35 (2016)
DOI:10.1111/apm.12566
Reference
  Authors
Salvadori M, Rosso G
  Title
Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN.
  Journal
World J Nephrol 5:308-20 (2016)
DOI:10.5527/wjn.v5.i4.308
Reference
  Authors
Floege J, Amann K
  Title
Primary glomerulonephritides.
  Journal
Lancet 387:2036-48 (2016)
DOI:10.1016/S0140-6736(16)00272-5
LinkDB

» Japanese version

DBGET integrated database retrieval system