KEGG   DISEASE: Dyslexia
Entry
H01899                      Disease                                
Name
Dyslexia
Description
Dyslexia is defined by severe difficulties in reading acquisition, often accompanied by spelling difficulties and affects a large number of people (5-10%). It is caused by multiple genetic and environmental risk factors as well as their interplay. Several candidate genes have been identified in the past decade. However, effects of individual genetic variations on dyslexia-associated deficits are only moderate. At the brain level, dyslexia is associated with aberrant structure and function, particularly in left hemisphere reading-language networks.
Category
Mental and behavioural disorder
Brite
Human diseases in ICD-11 classification [BR:br08403]
 21 Symptoms, signs or clinical findings, not elsewhere classified
  Symptoms, signs or clinical findings of the nervous system
   Symptoms or signs involving the nervous system
    MB4B  Symbolic dysfunctions
     H01899  Dyslexia
Gene
(DYX1) DNAAF4 [HSA:161582] [KO:K19758]
(DYX2) AAVR [HSA:9856] [KO:K24403]
Other DBs
ICD-11: MB4B.0
MeSH: D004410
OMIM: 127700 600202
Reference
  Authors
Peterson RL, Pennington BF
  Title
Developmental dyslexia.
  Journal
Annu Rev Clin Psychol 11:283-307 (2015)
DOI:10.1146/annurev-clinpsy-032814-112842
Reference
  Authors
Svensson I, Nilsson S, Wahlstrom J, Jernas M, Carlsson LM, Hjelmquist E
  Title
Familial dyslexia in a large Swedish family: a whole genome linkage scan.
  Journal
Behav Genet 41:43-9 (2011)
DOI:10.1007/s10519-010-9395-4
Reference
  Authors
Shastry BS
  Title
Developmental dyslexia: an update.
  Journal
J Hum Genet 52:104-9 (2007)
DOI:10.1007/s10038-006-0088-z
Reference
  Authors
Mannel C, Meyer L, Wilcke A, Boltze J, Kirsten H, Friederici AD
  Title
Working-memory endophenotype and dyslexia-associated genetic variant predict dyslexia phenotype.
  Journal
Cortex 71:291-305 (2015)
DOI:10.1016/j.cortex.2015.06.029
Reference
PMID:12954984 (DYX1)
  Authors
Taipale M, Kaminen N, Nopola-Hemmi J, Haltia T, Myllyluoma B, Lyytinen H, Muller K, Kaaranen M, Lindsberg PJ, Hannula-Jouppi K, Kere J
  Title
A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain.
  Journal
Proc Natl Acad Sci U S A 100:11553-8 (2003)
DOI:10.1073/pnas.1833911100
Reference
PMID:15717286 (DYX2)
  Authors
Cope N, Harold D, Hill G, Moskvina V, Stevenson J, Holmans P, Owen MJ, O'Donovan MC, Williams J
  Title
Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia.
  Journal
Am J Hum Genet 76:581-91 (2005)
DOI:10.1086/429131
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