KEGG DISEASE: Intrahepatic cholestasis of pregnancy

KEGG

DISEASE: Intrahepatic cholestasis of pregnancy

Entry

H02193                      Disease

Name

Intrahepatic cholestasis of pregnancy;
Obstetric cholestasis

Description

Intrahepatic cholestasis of pregnancy (ICP), also called obstetric cholestasis, is the most common pregnancy-specific liver disease. Classic symptoms include generalized pruritus that commonly includes the palms and soles, and biochemical evidence of elevated bile acids, with or without elevated liver function tests (LFTs). The etiology of ICP is influenced by a combination of genetic, endocrine, and environmental factors. Risk factors for ICP include multiple pregnancy, in vitro fertilization, advanced maternal age, history of prior affected pregnancy, positive family history, and hepatitis C infection.

Category

Digestive system disease

Brite

Human diseases in ICD-11 classification [BR:br08403]
18 Pregnancy, childbirth or the puerperium
  Certain specified maternal disorders predominantly related to pregnancy
   JA65  Maternal care for other conditions predominantly related to pregnancy
    H02193  Intrahepatic cholestasis of pregnancy

Pathway

Bile secretion

Gene

(ICP1) ATP8B1 [HSA:5205] [KO:K01530]
(ICP3) ABCB4 [HSA:5244] [KO:K05659]

Other DBs

ICD-11:

MeSH:

OMIM:

Reference

Authors

Wood AM, Livingston EG, Hughes BL, Kuller JA

Title

Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management.

Journal

Obstet Gynecol Surv 73:103-109 (2018)
DOI:10.1097/OGX.0000000000000524

Reference

Authors

McIlvride S, Dixon PH, Williamson C

Title

Bile acids and gestation.

Journal

Mol Aspects Med 56:90-100 (2017)
DOI:10.1016/j.mam.2017.05.003

Reference

Authors

Ovadia C, Williamson C

Title

Intrahepatic cholestasis of pregnancy: Recent advances.

Journal

Clin Dermatol 34:327-34 (2016)
DOI:10.1016/j.clindermatol.2016.02.004

Reference

Authors

Mullenbach R, Bennett A, Tetlow N, Patel N, Hamilton G, Cheng F, Chambers J, Howard R, Taylor-Robinson SD, Williamson C

Title

ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy.

Journal

Gut 54:829-34 (2005)
DOI:10.1136/gut.2004.058115

Reference

Authors

de Vree JM, Jacquemin E, Sturm E, Cresteil D, Bosma PJ, Aten J, Deleuze JF, Desrochers M, Burdelski M, Bernard O, Oude Elferink RP, Hadchouel M

Title

Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis.

Journal

Proc Natl Acad Sci U S A 95:282-7 (1998)
DOI:10.1073/pnas.95.1.282

LinkDB

» Japanese version

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