KEGG   DISEASE: Primary amoebic meningoencephalitis (PAM)
Entry
H02399                      Disease                                
Name
Primary amoebic meningoencephalitis (PAM)
Description
Primary amoebic meningoencephalitis (PAM) is a perilous and devastating waterborne disease caused by Naegleria fowleri. N. fowleri is a free-living, thermophilic amoeba distributed worldwide in soil and warm freshwater. PAM is a rare but fatal disease usually affecting children and young adults all around the world. This acute infection is developed by the entry of N. fowleri through nasal cavity.
Category
Parasitic infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Parasitic diseases
   Nonintestinal protozoal diseases
    1F55  Naegleriasis
     H02399  Primary amoebic meningoencephalitis (PAM)
Genome-based classification of infectious diseases [BR:br08401]
 Parasitic infections (protists)
  Infections caused by Heterolobosea
   H02399  Primary amoebic meningoencephalitis (PAM)
Pathogen
Naegleria fowleri
Other DBs
ICD-11: 1F55
MeSH: D020808
Reference
PMID:25883507
  Authors
Shrestha GS, Parajuli NP, Shrestha PS, Acharya SP, Hamal R, Gajurel B, Khanal K, Marhatta MN
  Title
Primary amoebic meningoencephalitis.
  Journal
J Neurosci Rural Pract 6:284-6 (2015)
DOI:10.4103/0976-3147.153244
Reference
PMID:26259797
  Authors
Grace E, Asbill S, Virga K
  Title
Naegleria fowleri: pathogenesis, diagnosis, and treatment options.
  Journal
Antimicrob Agents Chemother 59:6677-81 (2015)
DOI:10.1128/AAC.01293-15
Reference
PMID:31612525
  Authors
Jahangeer M, Mahmood Z, Munir N, Waraich UE, Tahir IM, Akram M, Ali Shah SM, Zulfqar A, Zainab R
  Title
Naegleria fowleri: Sources of infection, pathophysiology, diagnosis, and management; a review.
  Journal
Clin Exp Pharmacol Physiol 47:199-212 (2020)
DOI:10.1111/1440-1681.13192
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