KEGG   DISEASE: AL amyloidosis
Entry
H02499                      Disease                                
Name
AL amyloidosis;
Immunoglobulin light chain amyloidosis
Description
Immunoglobulin light chain (AL) amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis is a disorder of plasma cells or less commonly B cells that produce misfolded immunoglobulin light chain that deposits in tissues of a variety of organs causing organ dysfunction. Commonly affected organs include the heart, kidney, liver, soft tissues, peripheral and/or autonomic nerves, and the gastrointestinal tract.
Category
Endocrine and metabolic disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
 05 Endocrine, nutritional or metabolic diseases
  Metabolic disorders
   Other metabolic disorders
    5D00  Amyloidosis
     H02499  AL amyloidosis
Drug
Daratumumab and hyaluronidase [DR:D11967]
Other DBs
ICD-11: 5D00.0
ICD-10: E85.8
MeSH: D000075363
Reference
  Authors
Merlini G
  Title
AL amyloidosis: from molecular mechanisms to targeted therapies.
  Journal
Hematology Am Soc Hematol Educ Program 2017:1-12 (2017)
DOI:10.1182/asheducation-2017.1.1
Reference
  Authors
Sidiqi MH, Gertz MA
  Title
Daratumumab for the treatment of AL amyloidosis.
  Journal
Leuk Lymphoma 60:295-301 (2019)
DOI:10.1080/10428194.2018.1485914
LinkDB

» Japanese version

DBGET integrated database retrieval system