Seborrheic keratosis is one of the most common benign epidermal tumors that associates with increased age. The lesions manifest clinically as acquired, well-demarcated brownish papules or plaques with a verrucous surface that predominantly localize at areas of the head, neck and trunk. Seborrheic keratoses harbor multiple somatic alterations. Despite the lack of malignant potential, most of the lesions carry at least one mutation in a well-characterized oncogene. It has been reported that oncogenic PIK3CA mutations occur in epidermal nevi [DS:H02627] and seborrheic keratoses.
Category
Neoplasm
Brite
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Benign neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
Benign non-mesenchymal neoplasms
Benign cutaneous neoplasms
2F21 Benign keratinocytic acanthomas
H02921 Seborrheic keratosis
Hafner C, Lopez-Knowles E, Luis NM, Toll A, Baselga E, Fernandez-Casado A, Hernandez S, Ribe A, Mentzel T, Stoehr R, Hofstaedter F, Landthaler M, Vogt T, Pujol RM, Hartmann A, Real FX
Title
Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.
