KEGG   DISEASE: Pleomorphic salivary gland adenoma
Entry
H02922                      Disease                                
Name
Pleomorphic salivary gland adenoma
Description
Pleomorphic salivary gland adenoma (PSA) is the most common salivary gland neoplasm. Fusions involving PLAG1 locus were first discovered in pleomorphic adenoma  in 1997. PLAG1 gene rearrangement is the most common genetic abnormality in pleomorphic adenoma, resulting in overexpression of PLAG1 protein. PLAG1 is a zinc finger transcription factor and a proto-oncogene located on chromosome 8q12.
Category
Neoplasm
Brite
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Benign neoplasms, except of lymphoid, haematopoietic, central nervous system or related tissues
   Benign non-mesenchymal neoplasms
    2E91  Benign neoplasm of major salivary glands
     H02922  Pleomorphic salivary gland adenoma
Gene
PLAG1 [HSA:5324] [KO:K19484]
Other DBs
ICD-11: 2E91
OMIM: 181030
Reference
PMID:16736500
  Authors
Asp J, Persson F, Kost-Alimova M, Stenman G
  Title
CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas.
  Journal
Genes Chromosomes Cancer 45:820-8 (2006)
DOI:10.1002/gcc.20346
Reference
PMID:28796899
  Authors
Katabi N, Xu B, Jungbluth AA, Zhang L, Shao SY, Lane J, Ghossein R, Antonescu CR
  Title
PLAG1 immunohistochemistry is a sensitive marker for pleomorphic adenoma: a comparative study with PLAG1 genetic abnormalities.
  Journal
Histopathology 72:285-293 (2018)
DOI:10.1111/his.13341
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