KEGG   PATHWAY: map00621
Entry
map00621                    Pathway                                

Name
Dioxin degradation
Description
Dioxins and dioxin-like compounds, including PCDDs, PCDFs and PCBs, are persistent organic pollutants (POPs) that are resistant to environmental degradation. However, POPs can be degraded by certain microorganisms with acquisition of a novel set of enzymes, such as biphenyl degradation by Paraburkholderia xenovorans LB400 involving four novel enzymes encoded in operon-like structures [MD:M00543]. DDT, another POP, and carbazol are also known to be degraded in similar pathways.
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
map00621  Dioxin degradation
map00621

Module
M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate [PATH:map00621]
M00544  Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate [PATH:map00621]
Other DBs
UMBBD: dpd dbf bph cbp car ddt
Reference
  Authors
Nojiri H, Omori T.
  Title
Molecular bases of aerobic bacterial degradation of dioxins: involvement of angular dioxygenation.
  Journal
Biosci Biotechnol Biochem 66:2001-16 (2002)
DOI:10.1271/bbb.66.2001
Reference
  Authors
Jin S, Zhu T, Xu X, Xu Y.
  Title
Biodegradation of dibenzofuran by Janibacter terrae strain XJ-1.
  Journal
Curr Microbiol 53:30-6 (2006)
DOI:10.1007/s00284-005-0180-1
Reference
  Authors
Nojiri H, Habe H, Omori T.
  Title
Bacterial degradation of aromatic compounds via angular dioxygenation.
  Journal
J Gen Appl Microbiol 47:279-305 (2001)
DOI:10.2323/jgam.47.279
Reference
  Authors
Kasuga K, Habe H, Chung JS, Yoshida T, Nojiri H, Yamane H, Omori T.
  Title
Isolation and characterization of the genes encoding a novel oxygenase component of angular dioxygenase from the gram-positive dibenzofuran-degrader Terrabacter sp. strain DBF63.
  Journal
Biochem Biophys Res Commun 283:195-204 (2001)
DOI:10.1006/bbrc.2001.4763
Reference
  Authors
Vezina J, Barriault D, Sylvestre M
  Title
Family shuffling of soil DNA to change the regiospecificity of Burkholderia xenovorans LB400 biphenyl dioxygenase.
  Journal
J Bacteriol 189:779-88 (2007)
DOI:10.1128/JB.01267-06
Reference
  Authors
Ouchiyama N, Miyachi S, Omori T
  Title
Cloning and nucleotide sequence of carbazole catabolic genes from Pseudomonas stutzeri strain OM1, isolated from activated sludge.
  Journal
J Gen Appl Microbiol 44:57-63 (1998)
DOI:10.2323/jgam.44.57
Reference
PMID:9244273
  Authors
Sato SI, Ouchiyama N, Kimura T, Nojiri H, Yamane H, Omori T
  Title
Cloning of genes involved in carbazole degradation of Pseudomonas sp. strain CA10: nucleotide sequences of genes and characterization of meta-cleavage enzymes and hydrolase.
  Journal
J Bacteriol 179:4841-9 (1997)
DOI:10.1128/JB.179.15.4841-4849.1997
Reference
  Authors
Nguyen PA, Trinh TH, Fukumitsu Y, Shimodaira J, Miyauchi K, Tokuda M, Kasai D, Masai E, Fukuda M
  Title
Gene cluster and regulation system for 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE) degradation in Janibacter sp.  TYM3221.
  Journal
J Biosci Bioeng 116:91-100 (2013)
DOI:10.1016/j.jbiosc.2013.01.007
Related
pathway
map00020  Citrate cycle (TCA cycle)
map00350  Tyrosine metabolism
map00362  Benzoate degradation
map00364  Fluorobenzoate degradation
map00620  Pyruvate metabolism
map00627  Aminobenzoate degradation
KO pathway
ko00621   
LinkDB

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