| Entry |
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| Name |
Mutation-inactivated PRLR to PRL-JAK-STAT signaling pathway
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| Definition |
PRL // PRLR* // JAK2 -> STAT5 |
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| Expanded |
5617 // 5618v1 // 3717 -> (6776,6777) |
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| Class |
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| Type |
Variant
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| Disease |
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| Gene |
| 5618 | PRLR; prolactin receptor |
| 3717 | JAK2; Janus kinase 2 |
| 6776 | STAT5A; signal transducer and activator of transcription 5A |
| 6777 | STAT5B; signal transducer and activator of transcription 5B |
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| Variant |
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| Reference |
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| Authors |
Newey PJ, Gorvin CM, Cleland SJ, Willberg CB, Bridge M, Azharuddin M, Drummond RS, van der Merwe PA, Klenerman P, Bountra C, Thakker RV |
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| Title |
Mutant prolactin receptor and familial hyperprolactinemia. |
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| Journal |
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| Reference |
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| Authors |
Schuff KG, Hentges ST, Kelly MA, Binart N, Kelly PA, Iuvone PM, Asa SL, Low MJ |
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| Title |
Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms. |
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| Journal |
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| LinkDB |
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