KEGG   NETWORK: N01267
Entry
N01267                      Network                                
Name
KSHV vIL6 to IL6R signaling
Definition
vIL6 -> (IL6R+IL6ST)
  Expanded
K21670 -> (3570+3572)
Class
nt06150 Cytokine-cytokine receptor interaction (viruses)
Type
Pathogen
Pathway
hsa04061  Viral protein interaction with cytokine and cytokine receptor
Disease
H00041  Kaposi sarcoma
Gene
3570  IL6R; interleukin 6 receptor
3572  IL6ST; interleukin 6 signal transducer
Perturbant
K21670 (vIL6)  vIL6; KSHV interleukin 6
Reference
  Authors
Li H, Wang H, Nicholas J
  Title
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
  Journal
J Virol 75:3325-34 (2001)
DOI:10.1128/JVI.75.7.3325-3334.2001
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