Streptococcus pneumoniae is a common causative pathogen in community-acquired respiratory tract infections (RTIs), including acute otitis media, acute bacterial exacerbations of chronic bronchitis, acute bacterial sinusitis, and community-acquired pneumonia. It is also a major cause of bacteremia. Pneumococcal antibiotic resistance towards different families of antibiotics, in particular, penicillin and the macrocodes, continues to be a much-debated issue. The main mechanism of resistance in clinical isolates of S. pneumoniae involves the alteration of penicillin target proteins, the so-called penicillin binding protein (PBPs), which cause reduced affinities and/or binding capacities for the antibiotic molecule.
Category
Bacterial infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
21 Symptoms, signs or clinical findings, not elsewhere classified
General symptoms, signs or clinical findings
Finding of microorganism resistant to antimicrobial drugs
MG51 Finding of gram positive bacteria resistant to antimicrobial drugs
H01423 Penicillin-resistant Streptococcus pneumoniae infection
Genome-based classification of infectious diseases [BR:br08401]
Bacterial infections
Infections caused by Gram-positive bacteria
H01423 Penicillin-resistant Streptococcus pneumoniae infection
Infectious diseases by law in Japan [br08406.html]
H01423
Current concepts in antimicrobial therapy against select gram-positive organisms: methicillin-resistant Staphylococcus aureus, penicillin-resistant pneumococci, and vancomycin-resistant enterococci.
