KEGG   VARIANT: 1956v3
Entry
1956v3                      Variant                                
Name
First generation TKI-resistant EGFR mutation
Gene
EGFR  epidermal growth factor receptor [KO:K04361]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation T790M
ClinVar: 16613
dbSNP: rs121434569
Variation
exon 19 deletion
ClinVar: 177620
dbSNP: rs727504233
Variation
mutation L858R
ClinVar: 16609 376282 376280
dbSNP: rs121434568 rs1057519848 rs1057519847
Network
nt06210  ERK signaling
nt06214  PI3K signaling
nt06220  Calcium signaling
nt06266  Non-small cell lung cancer
  Element
N00014  Mutation-activated EGFR to RAS-ERK signaling pathway
N00024  Mutation-activated EGFR to PLCG-ERK signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N10006  Third-generation tyrosine kinase inhibitor to EGFR mutation
Disease
H00014  Non-small cell lung cancer
Drug target
Aumolertinib (DG03209): D12258 D12259
Lazertinib (DG03205): D11980 D12245
Osimertinib: D10766<JP/US>
Reference
PMID:28149837
  Authors
Sullivan I, Planchard D
  Title
Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line.
  Journal
Front Med (Lausanne) 3:76 (2016)
DOI:10.3389/fmed.2016.00076
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