Metabolism
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Global and overview maps
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01100 Metabolic pathways
01110 Biosynthesis of secondary metabolites
01120 Microbial metabolism in diverse environments
01200 Carbon metabolism
01210 2-Oxocarboxylic acid metabolism
01212 Fatty acid metabolism
01230 Biosynthesis of amino acids
01232 Nucleotide metabolism
01250 Biosynthesis of nucleotide sugars
01240 Biosynthesis of cofactors
01220 Degradation of aromatic compounds
01310 Nitrogen cycle
01320 Sulfur cycle
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Carbohydrate metabolism
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00010 Glycolysis / Gluconeogenesis
00020 Citrate cycle (TCA cycle)
00030 Pentose phosphate pathway
00040 Pentose and glucuronate interconversions
00051 Fructose and mannose metabolism
00052 Galactose metabolism
00053 Ascorbate and aldarate metabolism
00500 Starch and sucrose metabolism
00620 Pyruvate metabolism
00630 Glyoxylate and dicarboxylate metabolism
00640 Propanoate metabolism
00650 Butanoate metabolism
00660 C5-Branched dibasic acid metabolism
00562 Inositol phosphate metabolism
00566 Sulfoquinovose metabolism
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Energy metabolism
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00190 Oxidative phosphorylation
00195 Photosynthesis
00196 Photosynthesis - antenna proteins
00710 Carbon fixation by Calvin cycle
00720 Other carbon fixation pathways
00680 Methane metabolism
00910 Nitrogen metabolism
00920 Sulfur metabolism
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Lipid metabolism
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00061 Fatty acid biosynthesis
00062 Fatty acid elongation
00071 Fatty acid degradation
00073 Cutin, suberine and wax biosynthesis
00074 Mycolic acid biosynthesis
00100 Steroid biosynthesis
00120 Primary bile acid biosynthesis
00121 Secondary bile acid biosynthesis
00140 Steroid hormone biosynthesis
00561 Glycerolipid metabolism
00564 Glycerophospholipid metabolism
00565 Ether lipid metabolism
00600 Sphingolipid metabolism
00590 Arachidonic acid metabolism
00591 Linoleic acid metabolism
00592 alpha-Linolenic acid metabolism
01040 Biosynthesis of unsaturated fatty acids
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Nucleotide metabolism
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00230 Purine metabolism
00240 Pyrimidine metabolism
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Amino acid metabolism
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00250 Alanine, aspartate and glutamate metabolism
00260 Glycine, serine and threonine metabolism
00270 Cysteine and methionine metabolism
00280 Valine, leucine and isoleucine degradation
00290 Valine, leucine and isoleucine biosynthesis
00300 Lysine biosynthesis
00310 Lysine degradation
00220 Arginine biosynthesis
00330 Arginine and proline metabolism
00340 Histidine metabolism
00350 Tyrosine metabolism
00360 Phenylalanine metabolism
00380 Tryptophan metabolism
00400 Phenylalanine, tyrosine and tryptophan biosynthesis
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Metabolism of other amino acids
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00410 beta-Alanine metabolism
00430 Taurine and hypotaurine metabolism
00440 Phosphonate and phosphinate metabolism
00450 Selenocompound metabolism
00460 Cyanoamino acid metabolism
00470 D-Amino acid metabolism
00480 Glutathione metabolism
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Glycan biosynthesis and metabolism
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00520 Amino sugar and nucleotide sugar metabolism
00541 Biosynthesis of various nucleotide sugars
00510 N-Glycan biosynthesis
00513 Various types of N-glycan biosynthesis
00512 Mucin type O-glycan biosynthesis
00515 Mannose type O-glycan biosynthesis
00514 Other types of O-glycan biosynthesis
00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
00533 Glycosaminoglycan biosynthesis - keratan sulfate
00531 Glycosaminoglycan degradation
00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
00601 Glycosphingolipid biosynthesis - lacto and neolacto series
00603 Glycosphingolipid biosynthesis - globo and isoglobo series
00604 Glycosphingolipid biosynthesis - ganglio series
00511 Other glycan degradation
00540 Lipopolysaccharide biosynthesis
00542 O-Antigen repeat unit biosynthesis
00550 Peptidoglycan biosynthesis
00552 Teichoic acid biosynthesis
00571 Lipoarabinomannan (LAM) biosynthesis
00572 Arabinogalactan biosynthesis - Mycobacterium
00543 Exopolysaccharide biosynthesis
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Metabolism of cofactors and vitamins
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00730 Thiamine metabolism
00740 Riboflavin metabolism
00750 Vitamin B6 metabolism
00760 Nicotinate and nicotinamide metabolism
00770 Pantothenate and CoA biosynthesis
00780 Biotin metabolism
00785 Lipoic acid metabolism
00790 Folate biosynthesis
00670 One carbon pool by folate
00830 Retinol metabolism
00860 Porphyrin metabolism
00130 Ubiquinone and other terpenoid-quinone biosynthesis
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Metabolism of terpenoids and polyketides
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00900 Terpenoid backbone biosynthesis
00902 Monoterpenoid biosynthesis
00909 Sesquiterpenoid and triterpenoid biosynthesis
00904 Diterpenoid biosynthesis
00906 Carotenoid biosynthesis
00905 Brassinosteroid biosynthesis
00981 Insect hormone biosynthesis
00908 Zeatin biosynthesis
00903 Limonene degradation
00907 Pinene, camphor and geraniol degradation
01052 Type I polyketide structures
00522 Biosynthesis of 12-, 14- and 16-membered macrolides
01051 Biosynthesis of ansamycins
01059 Biosynthesis of enediyne antibiotics
01056 Biosynthesis of type II polyketide backbone
01057 Biosynthesis of type II polyketide products
00253 Tetracycline biosynthesis
00523 Polyketide sugar unit biosynthesis
01054 Nonribosomal peptide structures
01053 Biosynthesis of siderophore group nonribosomal peptides
01055 Biosynthesis of vancomycin group antibiotics
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Biosynthesis of other secondary metabolites
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00940 Phenylpropanoid biosynthesis
00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
00941 Flavonoid biosynthesis
00944 Flavone and flavonol biosynthesis
00942 Anthocyanin biosynthesis
00943 Isoflavonoid biosynthesis
00946 Degradation of flavonoids
00901 Indole alkaloid biosynthesis
00403 Indole diterpene alkaloid biosynthesis
00950 Isoquinoline alkaloid biosynthesis
00960 Tropane, piperidine and pyridine alkaloid biosynthesis
00996 Biosynthesis of various alkaloids
00232 Caffeine metabolism
00965 Betalain biosynthesis
00966 Glucosinolate biosynthesis
00402 Benzoxazinoid biosynthesis
00311 Penicillin and cephalosporin biosynthesis
00332 Carbapenem biosynthesis
00261 Monobactam biosynthesis
00331 Clavulanic acid biosynthesis
00521 Streptomycin biosynthesis
00524 Neomycin, kanamycin and gentamicin biosynthesis
00525 Acarbose and validamycin biosynthesis
00401 Novobiocin biosynthesis
00404 Staurosporine biosynthesis
00405 Phenazine biosynthesis
00333 Prodigiosin biosynthesis
00254 Aflatoxin biosynthesis
00975 Biosynthesis of various siderophores
00998 Biosynthesis of various antibiotics
00999 Biosynthesis of various plant secondary metabolites
00997 Biosynthesis of various other secondary metabolites
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Xenobiotics biodegradation and metabolism
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00362 Benzoate degradation
00627 Aminobenzoate degradation
00364 Fluorobenzoate degradation
00625 Chloroalkane and chloroalkene degradation
00361 Chlorocyclohexane and chlorobenzene degradation
00623 Toluene degradation
00622 Xylene degradation
00633 Nitrotoluene degradation
00642 Ethylbenzene degradation
00643 Styrene degradation
00791 Atrazine degradation
00930 Caprolactam degradation
00363 Bisphenol degradation
00621 Dioxin degradation
00626 Naphthalene degradation
00624 Polycyclic aromatic hydrocarbon degradation
00365 Furfural degradation
00984 Steroid degradation
00980 Metabolism of xenobiotics by cytochrome P450
00982 Drug metabolism - cytochrome P450
00983 Drug metabolism - other enzymes
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Chemical structure transformation maps
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01010 Overview of biosynthetic pathways
01060 Biosynthesis of plant secondary metabolites
01061 Biosynthesis of phenylpropanoids
01062 Biosynthesis of terpenoids and steroids
01063 Biosynthesis of alkaloids derived from shikimate pathway
01064 Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
01065 Biosynthesis of alkaloids derived from histidine and purine
01066 Biosynthesis of alkaloids derived from terpenoid and polyketide
01070 Biosynthesis of plant hormones
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Genetic Information Processing
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Transcription
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03020 RNA polymerase
03022 Basal transcription factors
03040 Spliceosome
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Translation
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03010 Ribosome
00970 Aminoacyl-tRNA biosynthesis
03013 Nucleocytoplasmic transport
03015 mRNA surveillance pathway
03008 Ribosome biogenesis in eukaryotes
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Folding, sorting and degradation
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03060 Protein export
04141 Protein processing in endoplasmic reticulum
04130 SNARE interactions in vesicular transport
04120 Ubiquitin mediated proteolysis
04122 Sulfur relay system
03050 Proteasome
03018 RNA degradation
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Replication and repair
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03030 DNA replication
03410 Base excision repair
03420 Nucleotide excision repair
03430 Mismatch repair
03440 Homologous recombination
03450 Non-homologous end-joining
03460 Fanconi anemia pathway
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Chromosome
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03082 ATP-dependent chromatin remodeling
03083 Polycomb repressive complex
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Information processing in viruses
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03230 Viral genome structure
03240 Viral replication
03250 Viral life cycle - HIV-1
03260 Virion - Human immunodeficiency virus
03271 Virion - Rotavirus
03262 Virion - Coronavirus
03261 Virion - Influenza virus
03263 Virion - Enterovirus
03264 Virion - Flavivirus and Alphavirus
03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
03273 Virion - Lassa virus and SFTS virus
03272 Virion - Hepatitis viruses
03266 Virion - Herpesvirus
03268 Virion - Orthopoxvirus
03267 Virion - Adenovirus
03259 Virion - Bacteriophages T4 and T7
03258 Virion - Bacteriophage lambda
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Environmental Information Processing
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Membrane transport
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02010 ABC transporters
02060 Phosphotransferase system (PTS)
03070 Bacterial secretion system
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Signal transduction
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02020 Two-component system
04010 MAPK signaling pathway
04013 MAPK signaling pathway - fly
04016 MAPK signaling pathway - plant
04011 MAPK signaling pathway - yeast
04012 ErbB signaling pathway
04014 Ras signaling pathway
04015 Rap1 signaling pathway
04310 Wnt signaling pathway
04330 Notch signaling pathway
04340 Hedgehog signaling pathway
04341 Hedgehog signaling pathway - fly
04350 TGF-beta signaling pathway
04390 Hippo signaling pathway
04391 Hippo signaling pathway - fly
04392 Hippo signaling pathway - multiple species
04370 VEGF signaling pathway
04371 Apelin signaling pathway
04630 JAK-STAT signaling pathway
04064 NF-kappa B signaling pathway
04668 TNF signaling pathway
04066 HIF-1 signaling pathway
04068 FoxO signaling pathway
04020 Calcium signaling pathway
04070 Phosphatidylinositol signaling system
04072 Phospholipase D signaling pathway
04071 Sphingolipid signaling pathway
04024 cAMP signaling pathway
04022 cGMP-PKG signaling pathway
04151 PI3K-Akt signaling pathway
04152 AMPK signaling pathway
04150 mTOR signaling pathway
04075 Plant hormone signal transduction
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Signaling molecules and interaction
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04080 Neuroactive ligand-receptor interaction
04082 Neuroactive ligand signaling
04081 Hormone signaling
04060 Cytokine-cytokine receptor interaction
04061 Viral protein interaction with cytokine and cytokine receptor
04512 ECM-receptor interaction
04514 Cell adhesion molecule (CAM) interaction
04517 IgSF CAM signaling
04518 Integrin signaling
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Cellular Processes
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Transport and catabolism
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04144 Endocytosis
04145 Phagosome
04142 Lysosome
04146 Peroxisome
04140 Autophagy - animal
04138 Autophagy - yeast
04136 Autophagy - other
04137 Mitophagy - animal
04139 Mitophagy - yeast
04148 Efferocytosis
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Cell growth and death
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04110 Cell cycle
04111 Cell cycle - yeast
04112 Cell cycle - Caulobacter
04113 Meiosis - yeast
04114 Oocyte meiosis
04210 Apoptosis
04214 Apoptosis - fly
04215 Apoptosis - multiple species
04216 Ferroptosis
04217 Necroptosis
04115 p53 signaling pathway
04218 Cellular senescence
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Cellular community - eukaryotes
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04510 Focal adhesion
04520 Adherens junction
04530 Tight junction
04540 Gap junction
04550 Signaling pathways regulating pluripotency of stem cells
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Cellular community - prokaryotes
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02024 Quorum sensing
05111 Biofilm formation - Vibrio cholerae
02025 Biofilm formation - Pseudomonas aeruginosa
02026 Biofilm formation - Escherichia coli
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Cell motility
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02030 Bacterial chemotaxis
02040 Flagellar assembly
04814 Motor proteins
04820 Cytoskeleton in muscle cells
04810 Regulation of actin cytoskeleton
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Organismal Systems
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Immune system
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04640 Hematopoietic cell lineage
04610 Complement and coagulation cascades
04611 Platelet activation
04613 Neutrophil extracellular trap formation
04620 Toll-like receptor signaling pathway
04624 Toll and Imd signaling pathway
04621 NOD-like receptor signaling pathway
04622 RIG-I-like receptor signaling pathway
04623 Cytosolic DNA-sensing pathway
04625 C-type lectin receptor signaling pathway
04650 Natural killer cell mediated cytotoxicity
04612 Antigen processing and presentation
04660 T cell receptor signaling pathway
04658 Th1 and Th2 cell differentiation
04659 Th17 cell differentiation
04657 IL-17 signaling pathway
04662 B cell receptor signaling pathway
04664 Fc epsilon RI signaling pathway
04666 Fc gamma R-mediated phagocytosis
04670 Leukocyte transendothelial migration
04672 Intestinal immune network for IgA production
04062 Chemokine signaling pathway
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Endocrine system
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04911 Insulin secretion
04910 Insulin signaling pathway
04922 Glucagon signaling pathway
04923 Regulation of lipolysis in adipocytes
04920 Adipocytokine signaling pathway
03320 PPAR signaling pathway
04929 GnRH secretion
04912 GnRH signaling pathway
04913 Ovarian steroidogenesis
04915 Estrogen signaling pathway
04914 Progesterone-mediated oocyte maturation
04917 Prolactin signaling pathway
04921 Oxytocin signaling pathway
04926 Relaxin signaling pathway
04935 Growth hormone synthesis, secretion and action
04918 Thyroid hormone synthesis
04919 Thyroid hormone signaling pathway
04928 Parathyroid hormone synthesis, secretion and action
04916 Melanogenesis
04924 Renin secretion
04614 Renin-angiotensin system
04925 Aldosterone synthesis and secretion
04927 Cortisol synthesis and secretion
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Circulatory system
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04260 Cardiac muscle contraction
04261 Adrenergic signaling in cardiomyocytes
04270 Vascular smooth muscle contraction
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Digestive system
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04970 Salivary secretion
04971 Gastric acid secretion
04972 Pancreatic secretion
04976 Bile secretion
04973 Carbohydrate digestion and absorption
04974 Protein digestion and absorption
04975 Fat digestion and absorption
04979 Cholesterol metabolism
04977 Vitamin digestion and absorption
04981 Folate transport and metabolism
04980 Cobalamin transport and metabolism
04978 Mineral absorption
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Excretory system
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04962 Vasopressin-regulated water reabsorption
04960 Aldosterone-regulated sodium reabsorption
04961 Endocrine and other factor-regulated calcium reabsorption
04964 Proximal tubule bicarbonate reclamation
04966 Collecting duct acid secretion
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Nervous system
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04724 Glutamatergic synapse
04727 GABAergic synapse
04725 Cholinergic synapse
04728 Dopaminergic synapse
04726 Serotonergic synapse
04720 Long-term potentiation
04730 Long-term depression
04723 Retrograde endocannabinoid signaling
04721 Synaptic vesicle cycle
04722 Neurotrophin signaling pathway
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Sensory system
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04744 Phototransduction
04745 Phototransduction - fly
04740 Olfactory transduction
04742 Taste transduction
04750 Inflammatory mediator regulation of TRP channels
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Development and regeneration
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04320 Dorso-ventral axis formation
04360 Axon guidance
04361 Axon regeneration
04380 Osteoclast differentiation
04382 Cornified envelope formation
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Aging
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04211 Longevity regulating pathway
04212 Longevity regulating pathway - worm
04213 Longevity regulating pathway - multiple species
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Environmental adaptation
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04710 Circadian rhythm
04713 Circadian entrainment
04711 Circadian rhythm - fly
04712 Circadian rhythm - plant
04714 Thermogenesis
04626 Plant-pathogen interaction
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Human Diseases
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Cancer: overview
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05200 Pathways in cancer
05202 Transcriptional misregulation in cancer
05206 MicroRNAs in cancer
05205 Proteoglycans in cancer
05204 Chemical carcinogenesis - DNA adducts
05207 Chemical carcinogenesis - receptor activation
05208 Chemical carcinogenesis - reactive oxygen species
05203 Viral carcinogenesis
05230 Central carbon metabolism in cancer
05231 Choline metabolism in cancer
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
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Cancer: specific types
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05210 Colorectal cancer
05212 Pancreatic cancer
05225 Hepatocellular carcinoma
05226 Gastric cancer
05214 Glioma
05216 Thyroid cancer
05221 Acute myeloid leukemia
05220 Chronic myeloid leukemia
05217 Basal cell carcinoma
05218 Melanoma
05211 Renal cell carcinoma
05219 Bladder cancer
05215 Prostate cancer
05213 Endometrial cancer
05224 Breast cancer
05222 Small cell lung cancer
05223 Non-small cell lung cancer
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Infectious disease: viral
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05166 Human T-cell leukemia virus 1 infection
05170 Human immunodeficiency virus 1 infection
05161 Hepatitis B
05160 Hepatitis C
05171 Coronavirus disease - COVID-19
05164 Influenza A
05162 Measles
05168 Herpes simplex virus 1 infection
05163 Human cytomegalovirus infection
05167 Kaposi sarcoma-associated herpesvirus infection
05169 Epstein-Barr virus infection
05165 Human papillomavirus infection
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Infectious disease: bacterial
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05110 Vibrio cholerae infection
05120 Epithelial cell signaling in Helicobacter pylori infection
05130 Pathogenic Escherichia coli infection
05132 Salmonella infection
05131 Shigellosis
05135 Yersinia infection
05133 Pertussis
05134 Legionellosis
05150 Staphylococcus aureus infection
05152 Tuberculosis
05100 Bacterial invasion of epithelial cells
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Infectious disease: parasitic
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05146 Amoebiasis
05144 Malaria
05145 Toxoplasmosis
05140 Leishmaniasis
05142 Chagas disease
05143 African trypanosomiasis
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Immune disease
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05310 Asthma
05322 Systemic lupus erythematosus
05323 Rheumatoid arthritis
05320 Autoimmune thyroid disease
05321 Inflammatory bowel disease
05330 Allograft rejection
05332 Graft-versus-host disease
05340 Primary immunodeficiency
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Neurodegenerative disease
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05010 Alzheimer disease
05012 Parkinson disease
05014 Amyotrophic lateral sclerosis
05016 Huntington disease
05017 Spinocerebellar ataxia
05020 Prion disease
05022 Pathways of neurodegeneration - multiple diseases
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Substance dependence
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05030 Cocaine addiction
05031 Amphetamine addiction
05032 Morphine addiction
05033 Nicotine addiction
05034 Alcoholism
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Cardiovascular disease
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05417 Lipid and atherosclerosis
05418 Fluid shear stress and atherosclerosis
05410 Hypertrophic cardiomyopathy
05412 Arrhythmogenic right ventricular cardiomyopathy
05414 Dilated cardiomyopathy
05415 Diabetic cardiomyopathy
05416 Viral myocarditis
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Endocrine and metabolic disease
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04930 Type II diabetes mellitus
04940 Type I diabetes mellitus
04950 Maturity onset diabetes of the young
04936 Alcoholic liver disease
04932 Non-alcoholic fatty liver disease
04931 Insulin resistance
04933 AGE-RAGE signaling pathway in diabetic complications
04934 Cushing syndrome
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Drug resistance: antimicrobial
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01501 beta-Lactam resistance
01502 Vancomycin resistance
01503 Cationic antimicrobial peptide (CAMP) resistance
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Drug resistance: antineoplastic
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01521 EGFR tyrosine kinase inhibitor resistance
01524 Platinum drug resistance
01523 Antifolate resistance
01522 Endocrine resistance
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Drug Development
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Chronology: Antiinfectives
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07011 Penicillins
07012 Cephalosporins - parenteral agents
07013 Cephalosporins - oral agents
07021 Aminoglycosides
07019 Tetracyclines
07020 Macrolides and ketolides
07014 Quinolones
07023 Rifamycins
07026 Antifungal agents
07044 Antiviral agents
07053 Anti-HIV agents
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Chronology: Antineoplastics
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07040 Antineoplastics - alkylating agents
07041 Antineoplastics - antimetabolic agents
07042 Antineoplastics - agents from natural products
07043 Antineoplastics - hormones
07045 Antineoplastics - protein kinase inhibitors
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Chronology: Nervous system agents
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07032 Hypnotics
07030 Anxiolytics
07033 Anticonvulsants
07015 Local analgesics
07039 Opioid analgesics
07028 Antipsychotics
07029 Antipsychotics - phenothiazines
07031 Antipsychotics - butyrophenones
07027 Antidepressants
07056 Agents for Alzheimer-type dementia
07057 Antiparkinsonian agents
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Chronology: Other drugs
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07055 Sulfonamide derivatives - overview
07016 Sulfonamide derivatives - sulfa drugs
07017 Sulfonamide derivatives - diuretics
07018 Sulfonamide derivatives - hypoglycemic agents
07037 Antiarrhythmic drugs
07038 Antiulcer drugs
07046 Immunosuppressive agents
07047 Osteoporosis drugs
07048 Antimigraines
07049 Antithrombosis agents
07050 Antirheumatics - DMARDs and biological agents
07051 Antidiabetics
07052 Antidyslipidemic agents
07054 Antiglaucoma agents
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Target-based classification: G protein-coupled receptors
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07220 Cholinergic and anticholinergic drugs
07215 alpha-Adrenergic receptor agonists/antagonists
07214 beta-Adrenergic receptor agonists/antagonists
07213 Dopamine receptor agonists/antagonists
07212 Histamine H1 receptor antagonists
07227 Histamine H2/H3 receptor agonists/antagonists
07211 Serotonin receptor agonists/antagonists
07228 Eicosanoid receptor agonists/antagonists
07224 Opioid receptor agonists/antagonists
07229 Angiotensin receptor and endothelin receptor antagonists
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Target-based classification: Nuclear receptors
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07225 Glucocorticoid and mineralocorticoid receptor agonists/antagonists
07226 Progesterone, androgen and estrogen receptor agonists/antagonists
07223 Retinoic acid receptor (RAR) and retinoid X receptor (RXR) agonists/antagonists
07222 Peroxisome proliferator-activated receptor (PPAR) agonists
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Target-based classification: Ion channels
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07221 Nicotinic cholinergic receptor antagonists
07230 GABA-A receptor agonists/antagonists
07036 Calcium channel blocking drugs
07231 Sodium channel blocking drugs
07232 Potassium channel blocking and opening drugs
07235 N-Methyl-D-aspartic acid (NMDA) receptor antagonists
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Target-based classification: Transporters
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07233 Ion transporter inhibitors
07234 Neurotransmitter transporter inhibitors
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Target-based classification: Enzymes
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07216 Catecholamine transferase inhibitors
07219 Cyclooxygenase inhibitors
07024 HMG-CoA reductase inhibitors
07217 Renin-angiotensin system inhibitors
07218 HIV protease inhibitors
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Structure-based classification
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07025 Quinolines
07034 Eicosanoids
07035 Prostaglandins
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Skeleton-based classification
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07110 Benzoic acid family
07112 1,2-Diphenyl substitution family
07114 Naphthalene family
07117 Benzodiazepine family
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