Functional Hierarchies
KEGG BRITE is a collection of hierarchical classification systems capturing functional hierarchies of various biological objects, especially those represented as KEGG objects. They are represented as BRITE hierarchy files, also called hierarchical text (htext) files, supplemented with BRITE table files using html tables. BRITE hierarchy files may contain tab-delimited attributes that are added manually or computationally. BRITE table files focus more on such multi-column attributes rather than hierarchy relationships. In contrast to KEGG PATHWAY, which is limited to molecular interactions and reactions, KEGG BRITE incorporates many different types of relationships including:
KEGG BRITE is the reference database for brite mapping in KEGG Mapper.
Brite Identifiers
Each brite hierarchy/table is identified by the combination of 2-4 letter prefix code and 5 digit number (see KEGG Identifier). The prefix has the following meaning:
- br
- non-gene/protein reference hierarchy or table
- jp
- non-gene/protein reference hierarchy or table in Japanese
- ko
- gene/protein reference hiearchy for KO expansion
- <org>
- organism-specific hierarchy generated by converting KOs to gene identifiers
New browser "show_brite" is released
Pathway and Brite
- 08901
- KEGG pathway maps
- 08902
- BRITE hierarchy files
- 08904
- BRITE table files
1. Genes and Proteins
1.1 Orthologs, modules and networks (K/M/N nubmers)- 00001
- KEGG Orthology (KO)
- 00002
- KEGG modules
- 00003
- KEGG reaction modules
- 08907
- KEGG networks [variation maps]
- 01000
- Enzymes
- 01001
- Protein kinases
- 01009
- Protein phosphatases and associated proteins
- 01002
- Peptidases and inhibitors
- 01003
- Glycosyltransferases
- 01005
- Lipopolysaccharide biosynthesis proteins
- 01011
- Peptidoglycan biosynthesis and degradation proteins
- 01004
- Lipid biosynthesis proteins
- 01008
- Polyketide biosynthesis proteins
- 01006
- Prenyltransferases
- 01007
- Amino acid related enzymes
- 00199
- Cytochrome P450
- 00194
- Photosynthesis proteins
- 03000
- Transcription factors
- 03021
- Transcription machinery
- 03019
- Messenger RNA biogenesis
- 03041
- Spliceosome
- 03011
- Ribosome
- 03009
- Ribosome biogenesis
- 03016
- Transfer RNA biogenesis
- 03012
- Translation factors
- 03110
- Chaperones and folding catalysts
- 04131
- Membrane trafficking
- 04121
- Ubiquitin system
- 03051
- Proteasome
- 03032
- DNA replication proteins
- 03036
- Chromosome and associated proteins
- 03400
- DNA repair and recombination proteins
- 03029
- Mitochondrial biogenesis
- 02000
- Transporters
- 02044
- Secretion system
- 02042
- Bacterial toxins
- 02022
- Two-component system
- 02035
- Bacterial motility proteins
- 04812
- Cytoskeleton proteins
- 04147
- Exosome
- 02048
- Prokaryotic defense system
- 04030
- G protein-coupled receptors
- 04050
- Cytokine receptors
- 04054
- Pattern recognition receptors
- 03310
- Nuclear receptors
- 04040
- Ion channels
- 04031
- GTP-binding proteins
- 04052
- Cytokines and growth factors
- 04515
- Cell adhesion molecules
- 04090
- CD molecules
- 01504
- Antimicrobial resistance genes
- 03200
- Viral proteins
- 03210
- Viral fusion proteins New!
- 03100
- Non-coding RNAs
- 01553
- (table) Antimicrobial resistance: beta-lactamase genes
- 01554
- (table) Antimicrobial resistance: aminoglycoside resistance genes
- 01556
- (table) Antimicrobial resistance: tetracycline resistance genes
- 01555
- (table) Antimicrobial resistance: macrolide resistance genes
- 01557
- (table) Antimicrobial resistance: others
- 01800
- (table) Sequence data for EC numbers
- 01810
- (table) Sequence data for CYP nomenclature
- 01610
- (table) Ribosomal proteins
- 01611
- (table) RNA polymerases
- 01612
- (table) DNA polymerases
- 01613
- (table) Aminoacyl-tRNA synthetases
- 01601
- (table) Enzymes of 2-oxocarboxylic acid metabolism
- 01602
- (table) Dioxygenases
- 01600
- (table) Antimicrobial resistance: KEGG signatures
- 01620
- (table) Photosynthetic and chemosynthetic capacities
2. Compounds and Reactions
2.1 Compounds (C numbers)- 08001
- Compounds with biological roles
- 08002
- Lipids
- 08003
- Phytochemical compounds
- 08021
- Glycosides
- 08005
- Bioactive peptides
- 08006
- Endocrine disrupting compounds
- 08007
- Pesticides
- 08008
- Carcinogens
- 08009
- Natural toxins
- 08010
- Target-based classification of compounds
- 08201
- Enzymatic reactions
- 08202
- IUBMB reaction hierarchy
- 08204
- Reaction class
- 08203
- Glycosyltransferase reactions
3. Drugs
3.1 Drug classifications (D numbers)- 08319
- (table) New drug approvals in the USA
- 08329
- (table) New drug approvals in Europe
- 08318
- (table) New drug approvals in Japan
- 08328
- (table) New drug approvals in the USA, Europe and Japan
- 08310
- Target-based classification of drugs
- 08309
- (table) Drug metabolizing enzymes and transporters
- 08341
- (table) Pharmacogenomic biomarkers
- 08324
- (table) Prodrugs
- 08317
- (table) Topical steroids potency
- 08315
- (table) Rx-to-OTC switch list in the USA
- 08314
- (table) Rx-to-OTC switch list in Japan
- 08311
- Drugs listed in the Japanese Pharmacopoeia
- 08321
- Essential oils
- 08322
- Medicinal herbs
- 08323
- Major components of natural products
- 08331
- Animal drugs in Japan
4. Diseases
4.1 Human diseases (H numbers)- 08402
- Human diseases [+ gene]
- 08401
- Infectious diseases [+ genome]
- 08403
- Human diseases in ICD-11 classification
- 08442
- (table) Tumor markers
- 08441
- (table) Cancer-associated carbohydrates
- 08431
- (table) Carbohydrates in viral and bacterial infections
5. Organisms and Cells
5.1 Organisms- 08601
- KEGG organisms
- 08610
- KEGG organisms in the NCBI taxonomy
- 08620
- KEGG viruses in the NCBI taxonomy
- 08602
- Animal classification
- 08603
- Plant classification
- 08605
- Plant pathogens
- 08501
- Human organ systems
- 08502
- Human cells
Binary Relationships
The following binary relation files may be used in the KEGG Mapper tool Join Brite to computationally extend the Brite hierarchy file.
K number to: COG GO TC CAZy
D number to: Target Enzyme Transporter
H number to: Human gene Pathogen genome
KEGG organism code to: Keywords
Codes and Abbreviations
- Nucleotide codes, amino acid codes, and genetic codes
- Monosaccharide codes
- Ketide and peptide codes
- Elements with biological roles
Last updated: January 14, 2021