Functional Hierarchies
KEGG BRITE is a collection of hierarchical classification systems capturing functional hierarchies of various biological objects, especially those represented as KEGG objects. They are represented as BRITE hierarchy files, also called hierarchical text (htext) files, supplemented with BRITE table files using html tables. BRITE hierarchy files may be associated with binary relation files containing various attributes of KEGG objects. The BRITE browser allows selection of such binary relations shown in the left panel for display as additional columns in the hierarchy. BRITE table files focus more on such multi-column attributes rather than hierarchy relationships. In comparison to KEGG PATHWAY, which is limited to molecular interactions and reactions, KEGG BRITE incorporates many different types of relationships including:
The brite hierarchy viewer linked from this page contains features of KEGG mapping, especially for joining binary relations.
Brite Identifiers
Each brite hierarchy/table is identified by the combination of 2-4 letter prefix code and 5 digit number (see KEGG Identifier). The prefix has the following meaning:
- br
- non-gene/protein reference hierarchy or table
- jp
- non-gene/protein reference hierarchy or table in Japanese
- ko
- gene/protein reference hiearchy for KO expansion
- <org>
- organism-specific hierarchy generated by converting KOs to gene identifiers
Pathway and Brite
- 08901
- KEGG pathway maps
- 08902
- BRITE hierarchy files
- 08904
- BRITE table files
- 08906
- BRITE binary relation files
1. Genes and Proteins
1.1 Orthologs, modules and networks (K/M/N nubmers)- 00001
- KEGG Orthology (KO)
- 00002
- KEGG modules
- 00003
- KEGG reaction modules
- 08907
- KEGG networks
- 01000
- Enzymes
- 01001
- Protein kinases
- 01009
- Protein phosphatases and associated proteins
- 01002
- Peptidases and inhibitors
- 01003
- Glycosyltransferases
- 01005
- Lipopolysaccharide biosynthesis proteins
- 01011
- Peptidoglycan biosynthesis and degradation proteins
- 01004
- Lipid biosynthesis proteins
- 01008
- Polyketide biosynthesis proteins
- 01006
- Prenyltransferases
- 01007
- Amino acid related enzymes
- 00199
- Cytochrome P450
- 00194
- Photosynthesis proteins
- 03000
- Transcription factors
- 03021
- Transcription machinery
- 03019
- Messenger RNA biogenesis
- 03041
- Spliceosome
- 03011
- Ribosome
- 03009
- Ribosome biogenesis
- 03016
- Transfer RNA biogenesis
- 03012
- Translation factors
- 03110
- Chaperones and folding catalysts
- 04131
- Membrane trafficking
- 04121
- Ubiquitin system
- 03051
- Proteasome
- 03032
- DNA replication proteins
- 03036
- Chromosome and associated proteins
- 03400
- DNA repair and recombination proteins
- 03029
- Mitochondrial biogenesis
- 02000
- Transporters
- 02044
- Secretion system
- 02042
- Bacterial toxins
- 02022
- Two-component system
- 02035
- Bacterial motility proteins
- 03037
- Cilium and associated proteins
- 04812
- Cytoskeleton proteins
- 04147
- Exosome
- 02048
- Prokaryotic defense system
- 04030
- G protein-coupled receptors
- 04050
- Cytokine receptors
- 04054
- Pattern recognition receptors
- 03310
- Nuclear receptors
- 04040
- Ion channels
- 04031
- GTP-binding proteins
- 04052
- Cytokines and growth factors
- 04515
- Cell adhesion molecules
- 04090
- CD molecules
- 01504
- Antimicrobial resistance genes
- 03200
- Viral proteins
- 03210
- Viral fusion proteins
- 03220
- (table) Virus entry
- 03222
- (table) Virus entry: animal viruses
- 03223
- (table) Viral network perturbations
- 03100
- Non-coding RNAs
- 01610
- (table) Ribosomal proteins
- 01611
- (table) RNA polymerases
- 01612
- (table) DNA polymerases
- 01613
- (table) Aminoacyl-tRNA synthetases
- 01601
- (table) Enzymes of 2-oxocarboxylic acid metabolism
- 01602
- (table) Dioxygenases
- 01600
- (table) Antimicrobial resistance: KEGG signatures
- 01620
- (table) Photosynthetic and chemosynthetic capacities
- 01553
- (table) Antimicrobial resistance: beta-lactamase genes
- 01554
- (table) Antimicrobial resistance: aminoglycoside resistance genes
- 01556
- (table) Antimicrobial resistance: tetracycline resistance genes
- 01555
- (table) Antimicrobial resistance: macrolide resistance genes
- 01557
- (table) Antimicrobial resistance: other resistance genes
- 01800
- (table) Sequence data for EC numbers
- 01810
- (table) Sequence data for CYP nomenclature
2. Compounds and Reactions
2.1 Compounds (C numbers)- 08001
- Compounds with biological roles
- 08002
- Lipids
- 08003
- Phytochemical compounds
- 08005
- Bioactive peptides
- 08006
- Endocrine disrupting compounds
- 08007
- Pesticides
- 08009
- Natural toxins
- 08011
- (table) Secondary metabolites in pathway maps
- 08020
- (table) Nucleotide sugars
- 08021
- Glycosides
- 08012
- (table) Dietary phytochemicals
- 08110
- (table) Blood groups and carbohydrate antigens
- 08120
- O-antigens
- 08201
- Enzymatic reactions
- 08202
- IUBMB reaction hierarchy
- 08204
- Reaction class
- 08203
- Glycosyltransferase reactions
- 08210
- (table) Overall reactions New!
3. Drugs
3.1 Drug classifications (D numbers)- 08303
- Anatomical Therapeutic Chemical (ATC) classification
- 08302
- USP drug classification
- 08301
- Therapeutic category of drugs in Japan
- 08313
- Classification of Japanese OTC drugs
- 08312
- Risk category of Japanese OTC drugs
- 08304
- Traditional Chinese Medicine in Japan
- 08305
- Crude drugs
- 08331
- Animal drugs in Japan
- 08319
- (table) New drug approvals in the USA
- 08329
- (table) New drug approvals in Europe
- 08318
- (table) New drug approvals in Japan
- 08328
- (table) New drug approvals in the USA, Europe and Japan
- 08330
- Drug groups
- 08332
- Drug classes
- 08310
- Target-based classification of drugs
- 08307
- Antimicrobials
- 08327
- Antimicrobials abbreviations
- 08309
- (table) Drug metabolizing enzymes and transporters
- 08341
- (table) Pharmacogenomic biomarkers
- 08324
- (table) Prodrugs
- 08317
- (table) Topical steroids potency
- 08315
- (table) Rx-to-OTC switch list in the USA
- 08314
- (table) Rx-to-OTC switch list in Japan
- 08311
- Drugs listed in the Japanese Pharmacopoeia
4. Diseases
4.1 Human diseases (H numbers)- 08442
- (table) Tumor markers
- 08441
- (table) Cancer-associated carbohydrates
- 08431
- (table) Carbohydrates in viral and bacterial infections
5. Organisms and Viruses
5.1 Taxonomy- 08620
- KEGG viruses in the NCBI taxonomy
- 08621
- KEGG viruses in taxonomic ranks
- 08622
- (table) KEGG selected viruses
- 08605
- Plant pathogens
Codes and Abbreviations
- Nucleotide codes, amino acid codes, and genetic codes
- Monosaccharide codes
- Ketide and peptide codes
- Elements with biological roles
Last updated: December 7, 2023