Functional Hierarchies
KEGG BRITE is a collection of manually created hierarchical text (htext) files capturing functional hierarchies of various biological objects, especially those represented as KEGG objects. Some BRITE hierarchy files contain tab-delimited attributes that are added manually or computationally. BRITE table files are now used to focus more on such multi-column attributes rather than hierarchy relationships. In contrast to KEGG PATHWAY, which is limited to molecular interactions and reactions, KEGG BRITE incorporates many different types of relationships including:
KEGG BRITE is a reference database for Brite Mapping.
Brite Identifiers
Each brite hierarchy/table is identified by the combination of 2-4 letter prefix code and 5 digit number (see KEGG Identifier). The prefix has the following meaning:
- br
- non-gene/protein reference hierarchy or table
- jp
- non-gene/protein reference hierarchy or table in Japanese
- ko
- gene/protein reference hiearchy for KO expansion
- <org>
- organism-specific hierarchy generated by converting KOs to gene identifiers
Pathway and Brite
- 08901
- KEGG pathway maps
- 08902
- BRITE hierarchy files
- 08904
- BRITE table files
- 08907
- KEGG networks
1. Genes and Proteins
1.1 Orthologs and modules (K/M nubmers)- 00001
- KEGG Orthology (KO)
- 00002
- KEGG modules
- 00003
- KEGG reaction modules
- 01000
- Enzymes
- 01001
- Protein kinases
- 01009
- Protein phosphatases and associated proteins
- 01002
- Peptidases
- 01003
- Glycosyltransferases
- 01005
- Lipopolysaccharide biosynthesis proteins
- 01011
- Peptidoglycan biosynthesis and degradation proteins
- 01004
- Lipid biosynthesis proteins
- 01008
- Polyketide biosynthesis proteins
- 01006
- Prenyltransferases
- 01007
- Amino acid related enzymes
- 00199
- Cytochrome P450
- 00194
- Photosynthesis proteins
- 03000
- Transcription factors
- 03021
- Transcription machinery
- 03019
- Messenger RNA biogenesis
- 03041
- Spliceosome
- 03011
- Ribosome
- 03009
- Ribosome biogenesis
- 03016
- Transfer RNA biogenesis
- 03012
- Translation factors
- 03110
- Chaperones and folding catalysts
- 04131
- Membrane trafficking
- 04121
- Ubiquitin system
- 03051
- Proteasome
- 03032
- DNA replication proteins
- 03036
- Chromosome and associated proteins
- 03400
- DNA repair and recombination proteins
- 03029
- Mitochondrial biogenesis
- 02000
- Transporters
- 02044
- Secretion system
- 02042
- Bacterial toxins
- 02022
- Two-component system
- 02035
- Bacterial motility proteins
- 04812
- Cytoskeleton proteins
- 04147
- Exosome
- 02048
- Prokaryotic defense system
- 04030
- G protein-coupled receptors
- 04050
- Cytokine receptors
- 04054
- Pattern recognition receptors
- 03310
- Nuclear receptors
- 04040
- Ion channels
- 04031
- GTP-binding proteins
- 04052
- Cytokines and growth factors
- 04515
- Cell adhesion molecules
- 04090
- CD molecules
- 01504
- Antimicrobial resistance genes
- 03200
- Viral proteins
- 03100
- Non-coding RNAs
- 01553
- (table) Antimicrobial resistance: beta-lactamase genes
- 01554
- (table) Antimicrobial resistance: aminoglycoside resistance genes
- 01556
- (table) Antimicrobial resistance: tetracycline resistance genes
- 01555
- (table) Antimicrobial resistance: macrolide resistance genes
- 01557
- (table) Antimicrobial resistance: others
- 01800
- (table) Sequence data for EC numbers
- 01810
- (table) Sequence data for CYP nomenclature
- 01610
- (table) Ribosomal proteins
- 01611
- (table) RNA polymerases
- 01612
- (table) DNA polymerases
- 01601
- (table) Enzymes of 2-oxocarboxylic acid metabolism
- 01602
- (table) Dioxygenases
- 01600
- (table) Antimicrobial resistance: KEGG signatures
- 01620
- (table) Photosynthetic and chemosynthetic capacities
- 01621
- (table) Signaling modules
2. Compounds and Reactions
2.1 Compounds (C numbers)- 08001
- Compounds with biological roles
- 08002
- Lipids
- 08003
- Phytochemical compounds
- 08005
- Bioactive peptides
- 08006
- Endocrine disrupting compounds
- 08007
- Pesticides
- 08008
- Carcinogens
- 08009
- Natural toxins
- 08010
- Target-based classification of compounds
- 08201
- Enzymatic reactions
- 08202
- IUBMB reaction hierarchy
- 08204
- Reaction class
- 08203
- Glycosyltransferase reactions
3. Drugs
3.1 Drug classifications (D numbers)- 08310
- Target-based classification of drugs
- 08340
- (table) Antineoplastics
- 08350
- (table) Antiinfectives
- 08317
- (table) Topical steroids potency
- 08319
- (table) New drug approvals in the USA
- 08329
- (table) New drug approvals in Europe
- 08318
- (table) New drug approvals in Japan
- 08328
- (table) New drug approvals in the USA, Europe and Japan
- 08341
- (table) Pharmacogenomic biomarkers New version!
- 08315
- (table) Rx-to-OTC switch list in the USA
- 08314
- (table) Rx-to-OTC switch list in Japan
- 08311
- Drugs listed in the Japanese Pharmacopoeia
- 08331
- Animal drugs in Japan
- 08304
- Traditional Chinese Medicine in Japan
- 08305
- Crude drugs
- 08321
- Essential oils
- 08322
- Medicinal herbs
- 08323
- Major components of natural products
- 08324
- (table) Prodrugs
4. Diseases
4.1 Human diseases (H numbers)- 08402
- Human diseases [+ gene]
- 08401
- Infectious diseases [+ genome]
- 08403
- Human diseases in ICD-11 classification
- 08442
- (table) Tumor markers
- 08441
- (table) Cancer-accociated carbohydrates
- 08431
- (table) Carbohydrates in viral and bacterial infections
5. Organisms and Cells
5.1 Organisms- 08601
- KEGG organisms [+ keywords]
- 08610
- KEGG organisms in the NCBI taxonomy
- 08620
- KEGG viruses in the NCBI taxonomy
- 08602
- Animal classification
- 08603
- Plant classification
- 08605
- Plant pathogens
- 08607
- Endosymbionts
- 08501
- Human organ systems
- 08502
- Human cells
Brite Mapping
KEGG BRITE mapping is the process to map molecular datasets, especially large-scale datasets in genomics, transcriptomics, proteomics, and metabolomics, to the BRITE functional hierarchies for biological interpretation of higher-level systemic functions.
- Search Brite - basic brite mapping tool
- Search&Color Brite - advanced brite mapping tool
- Join Brite - tool to combine brite hierarchy and binary relation files
- Join Brite Table - tool to combine brite table and binary relation files
Binary Relationships
The following binary relation files may be used in the KEGG Mapper tool Join Brite to computationally extend the Brite hierarchy file.
K number to: COG GO TC CAZy
D number to: Target Enzyme Transporter
H number to: Human gene Pathogen genome
KEGG organism code to: Keywords
Codes and Abbreviations
- Nucleotide codes, amino acid codes, and genetic codes
- Monosaccharide codes
- Ketide and peptide codes
- Elements with biological roles
Last updated: May 20, 2019