Functional Hierarchies

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KEGG BRITE is a collection of hierarchical classification systems capturing functional hierarchies of various biological objects, especially those represented as KEGG objects. They are represented as BRITE hierarchy files, also called hierarchical text (htext) files, supplemented with BRITE table files using html tables. BRITE hierarchy files may be associated with binary relation files containing various attributes of KEGG objects. The BRITE browser allows selection of such binary relations shown in the left panel for display as additional columns in the hierarchy. BRITE table files focus more on such multi-column attributes rather than hierarchy relationships. In comparison to KEGG PATHWAY, which is limited to molecular interactions and reactions, KEGG BRITE incorporates many different types of relationships including: The brite hierarchy viewer linked from this page contains features of KEGG mapping, especially for joining binary relations.

Brite Identifiers

Each brite hierarchy/table is identified by the combination of 2-4 letter prefix code and 5 digit number (see KEGG Identifier). The prefix has the following meaning:
non-gene/protein reference hierarchy or table
non-gene/protein reference hierarchy or table in Japanese
gene/protein reference hiearchy for KO expansion
organism-specific hierarchy generated by converting KOs to gene identifiers

» Japanese
Pathway and Brite

1. Genes and Proteins

1.1 Orthologs and modules (K/M nubmers)
1.2 Protein families: metabolism (K numbers)
1.3 Protein families: genetic information processing (K numbers)
1.4 Protein families: signaling and cellular processes (K numbers)
1.5 Viral protein families (K numbers)
1.6 RNA family (K numbers)
1.7 Annotation guide
1.8 Sequence data collection

2. Compounds and Reactions

2.1 Compounds (C numbers)
(table) Nucleotide sugars
(table) Dietary phytochemicals
2.2 Glycans (G numbers)
2.3 Reactions (R/RC numbers)

3. Drugs

3.1 Drug classifications (D numbers)
3.2 Drug information (D numbers)

4. Diseases

4.1 Human diseases (H numbers)
4.2 Disease genes and markers

5. Organisms and Viruses

5.1 Taxonomy
5.2 Organism information

Codes and Abbreviations

Last updated: June 27, 2024