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Entry Name Description Category Pathway
H01847 Thrombocytopenia-absent radius syndrome
TAR syndrome
Thrombocytopenia-absent radius (TAR) syndrome is a rare autosomal recessive syndrome characterized by severe thrombocytopenia and bilateral defects in development of the radii at birth but with preservation ... Congenital malformation
H01848 Acquired idiopathic generalized anhidrosis Acquired idiopathic generalized anhidrosis (AIGA) is a rare condition, characterized by generalized absence of sweating without other autonomic and neurologic dysfunction. Most of the cases reported are ... Skin disease
H01849 Peripheral arteriovenous malformation Arteriovenous malformation (AVM) is a congenital vascular malformation with direct communication from arteries to veins (arteriovenous shunting) and lack of a normal capillary network. The behavior of ... Congenital malformation
H01850 Hartsfield syndrome
Holoprosencephaly, ectrodactyly, and cleft/lip palate
Harstfield syndrome is the rare and unique association of holoprosencephaly (HPE) and ectrodactyly, with or without cleft lip and palate, and variable additional features. HPE and ectrodactyly can occur ... Congenital malformation
H01851 Congenital scoliosis associated with rib anomalies Congenital scoliosis is a lateral curvature of the spine that is due to the presence of vertebral anomalies causing an imbalance in the longitudinal growth of the spine. Most congenital scoliosis is often ... Congenital malformation
H01852 Postaxial polydactyly Postaxial polydactyly (PAP) is one of the commonest congenital malformations. Both isolated and syndromic forms of PAP have been reported. PAP is characterized by duplication of the fifth finger/toe on ... Congenital malformation
H01853 Chronic nonspecific multiple ulcers of the small intestine Chronic nonspecific multiple ulcers of the small intestine (CNSU) are characterized by multiple thin ulcers and concentric stenosis. CNSU predominantly occurs in females and the symptoms, such as general ... Digestive system disease
H01854 Metacarpal 4-5 fusion Metacarpal 4-5 fusion (MF4) is a rare congenital malformation of the hands characterised by the partial or complete fusion of the fourth and fifth metacarpal bones. The anomaly manifests clinically as ... Congenital malformation
H01855 Biliary atresia Biliary atresia (BA) is a congenital, fibro-obliterative obstructive cholangiopathy. It can be a devastating disease in infants invariably leading, if untreated, to cirrhosis, liver failure and death. ... Congenital malformation
H01856 Cloacal exstrophy
Vesicointestinal fissure
Cloacal exstrophy is an extremely rare congenital complex deformity that is associated with anterior abdominal wall defects, reflex and exposure of the cloaca (uninterrupted ureter and bowel), aproctia ... Congenital malformation
H01857 Filippi syndrome
Syndactyly type 1 with microcephaly and intellectual disability
Filippi syndrome is a rare autosomal-recessive disorder characterized by mild to severe mental retardation, syndactyly of the fingers and toes, microcephaly, pre and postnatal growth retardation, and unusual ... Congenital malformation
H01858 Persistent cloaca Persistent cloaca is an uncommon congenital anomaly in which there is a single perineal opening for the urinary, gastrointestinal, and reproductive tracts. It is the most severe form of anorectal malformation ... Congenital malformation
H01859 Occipital horn syndrome Occipital horn syndrome (OHS), formerly known as Ehlers-Danlos syndrome type IX or X-linked cutis laxa, is a mildest form of Menkes disease (MD). MD and OHS are X-linked recessive disorders of impaired ... Congenital malformation
H01860 Abnormal pituitary gonadotropin secretion There are two pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Their general biological roles are the stimulation of testicular and ovarian functions via the regulation ... Endocrine and metabolic disease
H01861 Chromosome 15q24 microdeletion syndrome
Witteveen-Kolk syndrome
Chromosome 15q24 microdeletion syndrome is a rare microdeletion syndrome characterized by growth retardation, intellectual disability, and distinct facial features including long face with high anterior ... Chromosomal abnormality
H01862 Hypoparathyroidism Hypoparathyroidism is characterized by hypocalcemia and hyperphosphatemia resulting from insufficient or defective parathyroid hormone (PTH) action. PTH is a key calcium regulating hormone essential for ... Endocrine and metabolic disease
H01863 Atopic myelitis
Eosinophilic myelitis
Atopic myelitis, also described as idiopathic eosinophilic myelitis, is a rare disease that consists of localised and persistent inflammation of the spinal cord. It has been reported predominantly in Japan ... Immune system disease
H01864 Excessive secretion of growth hormone Excessive secretion of growth hormone (GH) causes acromegaly [DS:H01483] and pituitary gigantism [DS:H01618]. They have the same pathogenetic mechanism, but differ regarding the age of onset. Gigantism ... Endocrine and metabolic disease
H01865 Multicentric carpotarsal osteolysis syndrome Multicentric carpotarsal osteolysis syndrome (MCTO) is a rare skeletal dysplasia characterized by progressive bone resorption (osteolysis), predominantly (although not exclusively) of the carpal and tarsal ... Musculoskeletal disease
H01866 Pulmonary veno-occlusive disease
Pulmonary capillary hemangiomatosis
Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis (PCH) are rare diseases that are classified as a subgroup of pulmonary arterial hypertension (PAH). PVOD is histologically ... Cardiovascular disease
H01867 Congenital anomalies of kidney and urinary tract Congenital anomalies of the kidney and urinary tract (CAKUT) include a wide range of structural malformations resulting from defects in the morphogenesis of the kidney and of the urinary tract. CAKUT represent ... Congenital malformation
H01868 Mitral valve prolapse Mitral valve prolapse (MVP) is a very common clinical condition that refers to a systolic billowing of one or both mitral valve leaflets into the left atrium. MVP can be associated with significant mitral ... Cardiovascular disease
H01869 Megacystis microcolon intestinal hypoperistalsis syndrome Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a rare congenital anomaly with decreased muscular tone in the urinary tract and intestine. MMIHS is characterized by prenatal-onset ... Congenital malformation
H01870 Microhydranencephaly Microhydranencephaly (MHAC) is a serious developmental brain anomaly characterized by microcephaly with severe reduction of brain hemispheres and intracranial space filled with cerebrospinal fluid without ... Congenital malformation
H01871 Isolated hypoganglionosis Isolated hypoganglionosis (IHG) is an innervation disorder that provides diagnostic and management challenges secondary to ill-defined diagnostic criteria. The symptoms of IHG resemble classical Hirschsprung ... Digestive system disease
H01872 Microcephaly-capillary malformation syndrome Microcephaly-capillary malformation (MIC-CAP) syndrome is an autosomal recessive congenital neurocutaneous disorder characterized by severe microcephaly with progressive cortical atrophy, intractable epilepsy ... Congenital malformation
H01873 Obliterative bronchiolitis
Bronchiolitis obliterans
Obliterative bronchiolitis (OB), also known as bronchiolitis obliterans, is a rare but serious condition resulting in progressive and irreversible airway obstruction. This disease is the result of injury ... Respiratory system disease
H01874 Cronkhite-Canada syndrome Cronkhite-Canada syndrome (CCS) is a rare noninherited condition characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, and diarrhea. CCS is reported worldwide ... Digestive system disease
H01875 Infantile hepatic hemangioma Infantile hepatic hemangioma (IHH), although rare, is the most common benign hepatic vascular tumor in the first year of age. They are sub-classified in focal, multiple and diffuse lesions, based on degree ... Neoplasm
H01876 Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation
Microcephaly, lymphedema, chorioretinal dysplasia (MLCRD) syndrome
Chorioretinal dysplasia, microcephaly, and mental retardation (CDMMR) syndrome
Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR) is a rare autosomal dominant or sporadic condition characterised by variable expression of microcephaly, eye problems ... Congenital malformation
H01877 Chromosome 15q13.3 microdeletion syndrome Chromosome 15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders. The syndrome is caused by microdeletions in the 15q13.2q-13.3 region. This chromosomal region contains seven genes and ... Chromosomal abnormality
H01878 Al-Raqad syndrome Al-Raqad syndrome (ARS) is a novel clinical entity, and is an autosomal recessive disorder with anomalies in multiple organs. Its most salient phenotypes comprise severe growth delay, neurological defects ... Congenital malformation
H01879 Wiedemann-Steiner syndrome Wiedemann-Steiner Syndrome (WDSTS) is a rare autosomal dominant disorder characterized by hairy elbows, dysmorphic facial appearances (hypertelorism, thick eyebrows, downslanted and vertically narrow palpebral ... Congenital malformation
H01880 Autosomal recessive microcephaly and chorioretinopathy Autosomal-recessive microcephaly and chorioretinopathy (MCCRP) is a rare developmental disorder characterized by primary microcephaly, delayed psychomotor development, growth retardation with dwarfism ... Congenital malformation
H01881 Complex cortical dysplasia with other brain malformations Complex cortical dysplasia with other brain malformations (CDCBM) is a disorder of aberrant neuronal migration and disturbed axonal guidance. Patients exhibit mental retardation, strabismus combined with ... Congenital malformation
H01882 Asperger syndrome Asperger syndrome (AS), a behavioral disorder that is related to autism, is associated with abnormal social functioning and repetitive behaviors but not with a decrease in intelligence or linguistic functionality ... Mental and behavioural disorder
H01883 Nestor-Guillermo progeria syndrome Nestor-Guillermo progeria syndrome (NGPS) is a new hereditary progeroid syndrome characterized by early onset and slow progression of symptoms including poor growth, lipoatrophy, pseudosenile facial appearance ... Inherited metabolic disorder
H01884 Auriculocondylar syndrome
Question mark ears syndrome
Auriculocondylar syndrome (ACS) is a rare craniofacial malformation syndrome characterized by mandibular hypoplasia and question-mark ears (QME). QMEs, consisting of a specific defect at the lobe-helix ... Congenital malformation
H01885 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
MPPH syndrome
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH) is rare overgrowth disorder. MCAP [DS:H02153] and MPPH show very similar symptoms; the main symptoms are progressive megalencephaly ... Congenital malformation
H01886 Van den Ende-Gupta syndrome Van den Ende-Gupta syndrome (VDEGS) is a rare hereditary disorder with characteristic craniofacial and skeletal manifestations. Characteristic features of VDEGS include blepharophimosis, malar hypoplasia ... Congenital malformation
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